Supervisors from Mossakowski Medical Research Centre

apiwkowska@imdik.pan.pl

Agnieszka Piwkowska is a professor in the Mossakowski Medical Research Centre, Polish Academy of Sciences (MMRC PAS) where she has worked for 14 years. Since 2018 she has led the Laboratory of Molecular and Cellular Nephrology in Gdańsk. Piwkowska earned her PhD from the Medical University of Gdańsk and her MSc degree at the Technical University of Gdańsk. Her research interests lie in the area of diabetic nephropathy and insulin signaling pathways.

 

Research interests:

Diabetic nephropathy, podocyte biology, insulin resistance, filtration barrier permeability, kidney pathology.

Major publications:

Piwkowska  A. et al., (2013). Biochim Biophys Acta.

Piwkowska A. and Cell J. (2017). Physiol.

Rachubik et al., (2018). Cell Physiol Biochem.

Szrejder et al., (2020). Biochim Biophys Acta Mol Basis Dis.

Audzeyenka et al., (2020). Biochim Biophys Acta Mol Cell Res.

 mwegrzynowicz@imdik.pan.pl

@ http://www.imdik.pan.pl/en/researchgroups/laboratories/1203-laboratory-of-molecular-basis-ofneurodegeneration

Michał Węgrzynowicz has led the Laboratory of Molecular Basis of Neurodegeneration at the Mossakowski Medical Research Centre, Polish Academy of Sciences (MMRC PAS) since 2019. Following

his PhD at MMRC PAS, he was a postdoctoral fellow at Vanderbilt University in Nashville, TN in the United STates, where he worked in Prof. Aaron Bowman research group investigating heavy metal homeostasis in Huntington’s disease, and was involved in the development of novel transgenic mouse models of this disorder. He later moved to Cambridge University to join Prof. Maria Grazia Spillantini’s group, where he participated in several projects focused on understanding the mechanisms and consequences of alpha-synuclein aggregation as a primary causative factor in the pathogenesis of Parkinson’s disease, and as a potential target for novel, mechanism-based therapeutic strategies against this disorder.

Research interests:

Neurodegeneration, protein aggregation, Parkinson’s disease, Huntington’s disease, arginine metabolism.

Major publications:

Wegrzynowicz M., Bar-On D., Calo' L., Anichtchik O., Iovino M., Xia J., Ryazanov S., Leonov A., Giese A., Dalley J.W., Griesinger C., Ashery U., Spillantini M.G. (2019). “Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model”, Acta Neuropathol. 138(4):575-595.

Migdalska-Richards A., Wegrzynowicz M., Rusconi R., Deangeli G., Di Monte D.A., Spillantini M.G., Schapira A.H.V. (2017). “The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice”, Brain. 140(10):2706-2721.

Bichell T.J.V., Wegrzynowicz M., Tipps K.G., Bradley E.M., Uhouse M.A., Bryan M., Horning K., Fisher N., Dudek K., Halbesma T., Umashanker P., Stubbs A.D., Holt H.K., Kwakye G.F., Tidball A.M., Colbran R.J., Aschner M., Neely M.D., Di Pardo A., Maglione V., Osmand A., Bowman A.B. (2017). “Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model”, Biochim Biophys Acta Mol Basis Dis. 1863(6):1596-1604.

Wegrzynowicz M., Bichell T.J., Soares B.D., Loth M.K., McGlothan J.S., Mori S., Alikhan F.S., Hua K.,

Coughlin J.M., Holt H.K., Jetter C.S., Pomper M.G., Osmand A.P., Guilarte T.R., Bowman A.B. (2015). “Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype”, J Huntingtons Dis. 4(1):17-36.

Wegrzynowicz M., Holt H.K., Friedman D.B., Bowman A.B. (2012). “Changes in the striatal proteome of  YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese”, J Proteome Res. 11(2):1118-3.

 esalinska@imdik.pan.pl

@ http://www.imdik.pan.pl/pl/dzialalnosc-naukowa/zaklady-badawcze/64-zaklad-neurochemii

Prof. Salinska graduated from Warsaw University and started working first at Warsaw Medical Academy and then at MMRC PAS. She received her Ph.D. in this Institute, and afterward, she spent six years at The Open University, Milton Keynes, UK. First, she was at the Royal Society postdoctoral fellowship and Wellcome Trust Research Fellowship, and then she was hired as a research assistant.   Prof. Salinska is connected with the MMRC for more than 20 years. Since 2010, Prof. Salinska is the Head of the Neurochemistry Department in MMRC PAS. The main research interest is related mostly to brain ischemia, neurotoxicity, neurodegenerative diseases, and microRNA. Molecular processes involved in learning and memory formation are also the subject of investigation.

Research interests:

Brain ischemia, neurotoxicity, neurodegenerative diseases, microRNA, molecular processes.

Major publications:

Bratek E, Ziembowicz A, Salinska E. Antioxidants, 2020.

Bronisz A, Salińska E, Chiocca EA, Godlewski J. Cancers, 2020.

Krolik A, Diamandakis D, Zych A, Stafiej A, Salinska E. Neurobiol Learn Mem. 2020.

Godlewski J, Lenart J, Salinska E. Noncoding RNA. 2019; Bratek E, Ziembowicz A, Bronisz A, Salinska E. PLoS One. 2018.

 abronisz@imdik.pan.pl

@ Bronisz_profile

Dr. Agnieszka Bronisz is a Professor of Mossakowski Medical Research Institute (MMRI) in Warsaw, Poland. She has earned her Ph.D. degree in medical science, majoring in molecular neuropathology at the MMRI in 2001. Subsequently, she continued with her post-doctoral training in biochemistry at the Texas A&M University, Temple, TX, USA, and genetics at The Ohio State University Medical Center, Columbus, OH, USA (OSUMC). In 2008 she became a faculty member of OSUMC to develop her project in the field of cancer research. In 2012 she joined the Department of Neurosurgery as a faculty at Brigham and Women’s Hospital and Harvard Medical School, Boston, the USA, where she established her research group to study the cellular and extracellular effectors of cancer heterogeneity. In 2019 she was recruited to MMRI to lead the Tumor Microenvironment Laboratory.

Research interests:

Secretome, exosomes, ncRNAome.

Major publications:

Bronisz A, Rooj AK, Krawczyński K, Peruzzi P, Salińska E, Nakano I, Purow B, Chiocca EA, Godlewski J. The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Science Advances 2020; 6(51).

Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salinska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A. MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports 2017; 8(6):1497-505.

Mineo M, Ricklefs F, Rooj AK, Lyons SM, Ivanov P, Ansari KI, Nakano I, Chiocca EA, Godlewski J, Bronisz A. The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Reports 2016; 15(11):2500-9.

Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A. Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Research 2016; 76(10):2876-81.

Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pecot T, Rosol TJ, Cory S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE, Chiocca EA, Leone G, Ostrowski MC. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nature Cell Biology 2011; 14(2):159-67.

 jgodlewski@imdik.pan.pl

@ https://scholar.google.com/citations?user=V2aalqAAAAAJ&hl=en&oi=ao

Dr. Jakub Godlewski is the Neuro-Oncology team leader at Mossakowski Medical Research Institute (MMRI) Warsaw, Poland. He earned his Ph.D. in biology from the University of Warsaw in 2002. He conducted his post-doctoral training at the Texas A&M University, Temple, TX, USA and at The Ohio State University Medical Center, Columbus, OH, USA (OSUMC). In 2010 at the rank of Assistant Professor of OSUMC, he developed his investigation project in the field of non-coding RNA. In 2012 he joined the Department of Neurosurgery at Brigham and Women’s Hospital and Harvard Medical School, Boston, USA (BWH/HMS), where he established his research group to study the RNA species to advance anti-cancer therapy. In 2020 dr. Godlewski joined MMRI to further his research program for cancer treatment.

Research interests:

Non-coding RNA, glioblastoma, tumor microenvironment.

Major publications:

Bronisz A, Rooj AK, Krawczyński K, Peruzzi P, Salińska E, Nakano I, Purow B, Chiocca EA, Godlewski J. The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Science Advances (2020); 6(51). Epub 2020/12/18. doi: 10.1126/sciadv.abc0221. PubMed PMID: 33328224.

Rooj AK, Ricklefs F, Mineo M, Nakano I, Chiocca EA, Bronisz A, Godlewski J. MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Reports (2017); 19(10):2026-32. Epub 2017/06/08. doi: 10.1016/j.celrep.2017.05.040. PubMed PMID: 28591575; PMCID: PMC5514838.

Ansari KI, Ogawa D, Rooj AK, Lawler SE, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A, Godlewski J. Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Reports (2015); 11(6):902-9. Epub 2015/05/06. doi: 10.1016/j.celrep.2015.04.016. PubMed PMID: 25937278; PMCID: PMC44319045.

Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari K, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J. Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Research (2014); 74(3):738-50. Epub 2013/12/07. doi: 10.1158/0008-5472.CAN-13-2650. PubMed PMID: 24310399; PMCID: PMC3928601.

Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE. MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Molecular Cell (2010); 37(5):620-32. Epub 2010/03/17. doi: 10.1016/j.molcel.2010.02.018. PubMed PMID: 20227367; PMCID: PMC3125113.

Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Research (2008); 68(22):9125-30. doi: 10.1158/0008-5472.CAN-08-2629. PubMed PMID: 19010882.

 rfilipkowski@imdik.pan.pl 

Robert Kuba Filipkowski received his PhD at Nencki Institute in Warsaw, spent four years in Cold Spring Harbor Laboratory, NY, and is now a head of the Behavior and Metabolism Research Laboratory at Mossakowski Institute. At the lab, we investigate the ultrasonic vocalizations of mice and rats (relevant publications below). We have designed and developed new behavioral setups based on the playback of recorded vocalizations. It turns out rats emit a lot of vocalizations when presented with pre-recorded calls of other rats (see Olszyński et al. 2020). Particularly, we explore changes in the cardiovascular i.e. heart-rate, and behavioral parameters evoked by the playback during different states of the autonomic nervous system. Also, we describe new types of vocalizations as well as study and analyze exchange of vocalizations between couples and groups of rats as well as mice. Here, we investigate different types of vocalizations in search for their biological meaning and/or patterns of emissions and calls’ exchange. Our new project aims at establishing brain centers responsible for vocal ultrasonic exchange.

Research interests:

Behavior, language, stress, animal communication

Major publications:

Olszyński K.H., Polowy R., Małż M., Boguszewski P.M., Filipkowski R.K. 2020. Playback of alarm and appetitive calls differentially impacts vocal, heart-rate, and motor response in rats. iScience, 23, 101577, 2020.

Cieślik M., Gąssowska-Dobrowolska M., Jęśko H., Czapski G.A., Wilkaniec A., Zawadzka A., Dominiak A., Polowy R., Filipkowski R.K., Boguszewski P.M., Gewartowska M., Frontczak-Baniewicz M., Sun G.Y., Beversdorf D.Q., Adamczyk A. Maternal immune activation induces neuroinflammation and cortical synaptic deficits in the adolescent rat offspring. Int. J. Mol. Sci., 21:4097, 2020.

Gąssowska-Dobrowolska M., Cieślik M., Czapski G.A., Jęśko H., Frontczak-Baniewicz M., Gewartowska M., Dominiak A., Polowy R., Filipkowski R.K., Babiec L., Adamczyk A. Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders. Int. J. Mol. Sci., 21:3576, 2020.

Zieminska E., Toczylowska B., Diamandakis D., Hilgier W., Filipkowski R.K., Polowy R., Orzel J., Gorka M., Lazarewicz J.W. 2018. Glutamate, glutamine and GABA levels in rat brain measured using MRS, HPLC and NMR methods in study of two models of autism. Front. Mol. Neurosci., 2018. DOI: 10.3389/fnmol.2018.00418. eCollection 2018.

Ziemka-Nalecz M., Jaworska J., Sypecka J., Polowy R., Filipkowski R.K., Zalewska T. Sodium butyrate, a histone deacetylase inhibitor, exhibits neuroprotective/neurogenic effects in a rat model of neonatal hypoxia-ischemia. Mol. Neurobiol., 54:5300-18, 2017.

jsypecka@imdik.pan.pl

@ http://www.imdik.pan.pl/en/research-groups/departments/112-neurorepair-department

Joanna Sypecka graduated from Warsaw University (Faculty of Biology) and received her Ph.D. degree in medical science from Mossakowski Medical Research Institute (MMRI).  During the 6-month internship at Lausanne University Hospital (Switzerland) she got particularly interested in searching for effective therapies for neonates who experienced perinatal asphyxia resulting in white matter disorders. Since 2015 she has been the head of Ph. D. studies in MMRI, engaged in organizing didactic activity, and involved in  European projects in human capital. Since 2018 she has been the leader of NeuroRepair DepartmentHer research work is focused on the biology of glial cells, especially investigating the mechanisms of their response to various pathophysiological clues to elaborate and pre-clinical testing potential neuroreparative strategies.    

 

Research interests:  

Biology of glial cells, development of the central nervous system, myelination, white matter disorders, epigenetic regulation of cell commitment and differentiation, neuroreparative strategies  

 

Major publications: 

Janowska J, Gargas J, Ziemka-Nalecz M, Zalewska T, Sypecka J.(2020) Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells. Mol Neurobiol. 2020 Oct;57(10):4250-4268.  

Janowska J, Gargas J, Ziemka-Nalecz M, Zalewska T, Buzanska L, Sypecka J. (2019) Directed glial differentiation and transdifferentiation for neural tissue regeneration. Exp Neurol 319:112813.  

Janowska J, Ziemka-Nalecz M, Sypecka J (2018). The Differentiation of Rat Oligodendroglial Cells Is Highly Influenced by the Oxygen Tension: In Vitro Model Mimicking Physiologically Normoxic Conditions. Int J Mol Sci 24;19(2):331. 

Janowska J, Sypecka J. (2018) Therapeutic Strategies for Leukodystrophic Disorders Resulting from Perinatal Asphyxia: Focus on Myelinating Oligodendrocytes. Mol Neurobiol 55(5):4388-4402  

Ziemka-Nalecz M, Janowska J, Strojek L, Jaworska J, Zalewska T, Frontczak-Baniewicz M, Sypecka J (2018): Impact of neonatal hypoxia ischaemia on oligodendrocyte survival, maturation and myelinating potential. J Cell Mol Med 22(1):207-222  

Sypecka J, Ziemka-Nalecz M, Dragun-Szymczak P, Zalewska T (2017): A simple, xeno-free method for oligodendrocyte generation from human neural stem cells derived from umbilical cord: engagement of gelatinases in cell commitment and differentiation. J Tissue Eng Regen Med 11:1442- 

Jaworska J, Ziemka-Nalecz M, Sypecka JZalewska T, (2017): The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J  neuroinflammation. 14(1):34 IF=5.102; IF5=5.717; Q1 

Ziemka-Nalecz M, Jaworska J, Sypecka JPolowy R, Filipkowski RK, Zalewska T (2017): Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia. Mol Neurobiol. 54(7):5300-5318  

Sypecka JSarnowska A.(2014) The neuroprotective effect exerted by oligodendroglial progenitors on ischemically impaired hippocampal cells. Mol Neurobiol. 49(2):685-701. 

 

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