Supervisors from Mossakowski Medical Research Centre

apiwkowska@imdik.pan.pl

Agnieszka Piwkowska is a professor in the Mossakowski Medical Research Centre, Polish Academy of Sciences (MMRC PAS) where she has worked for 14 years. Since 2018 she has led the Laboratory of Molecular and Cellular Nephrology in Gdańsk. Piwkowska earned her PhD from the Medical University of Gdańsk and her MSc degree at the Technical University of Gdańsk. Her research interests lie in the area of diabetic nephropathy and insulin signaling pathways.

 

Research interests:

Diabetic nephropathy, podocyte biology, insulin resistance, filtration barrier permeability, kidney pathology.

Major publications:

Piwkowska  A. et al., (2013). Biochim Biophys Acta.

Piwkowska A. and Cell J. (2017). Physiol.

Rachubik et al., (2018). Cell Physiol Biochem.

Szrejder et al., (2020). Biochim Biophys Acta Mol Basis Dis.

Audzeyenka et al., (2020). Biochim Biophys Acta Mol Cell Res.

 mwegrzynowicz@imdik.pan.pl

@ http://www.imdik.pan.pl/en/researchgroups/laboratories/1203-laboratory-of-molecular-basis-ofneurodegeneration

Michał Węgrzynowicz has led the Laboratory of Molecular Basis of Neurodegeneration at the Mossakowski Medical Research Centre, Polish Academy of Sciences (MMRC PAS) since 2019. Following

his PhD at MMRC PAS, he was a postdoctoral fellow at Vanderbilt University in Nashville, TN in the United STates, where he worked in Prof. Aaron Bowman research group investigating heavy metal homeostasis in Huntington’s disease, and was involved in the development of novel transgenic mouse models of this disorder. He later moved to Cambridge University to join Prof. Maria Grazia Spillantini’s group, where he participated in several projects focused on understanding the mechanisms and consequences of alpha-synuclein aggregation as a primary causative factor in the pathogenesis of Parkinson’s disease, and as a potential target for novel, mechanism-based therapeutic strategies against this disorder.

 

Research interests:

Neurodegeneration, protein aggregation, Parkinson’s disease, Huntington’s disease, arginine metabolism.

 

Major publications:

Wegrzynowicz M., Bar-On D., Calo' L., Anichtchik O., Iovino M., Xia J., Ryazanov S., Leonov A., Giese A., Dalley J.W., Griesinger C., Ashery U., Spillantini M.G. (2019). “Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model”, Acta Neuropathol. 138(4):575-595.

Migdalska-Richards A., Wegrzynowicz M., Rusconi R., Deangeli G., Di Monte D.A., Spillantini M.G., Schapira A.H.V. (2017). “The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice”, Brain. 140(10):2706-2721.

Bichell T.J.V., Wegrzynowicz M., Tipps K.G., Bradley E.M., Uhouse M.A., Bryan M., Horning K., Fisher N., Dudek K., Halbesma T., Umashanker P., Stubbs A.D., Holt H.K., Kwakye G.F., Tidball A.M., Colbran R.J., Aschner M., Neely M.D., Di Pardo A., Maglione V., Osmand A., Bowman A.B. (2017). “Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model”, Biochim Biophys Acta Mol Basis Dis. 1863(6):1596-1604.

Wegrzynowicz M., Bichell T.J., Soares B.D., Loth M.K., McGlothan J.S., Mori S., Alikhan F.S., Hua K.,

Coughlin J.M., Holt H.K., Jetter C.S., Pomper M.G., Osmand A.P., Guilarte T.R., Bowman A.B. (2015). “Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype”, J Huntingtons Dis. 4(1):17-36.

Wegrzynowicz M., Holt H.K., Friedman D.B., Bowman A.B. (2012). “Changes in the striatal proteome of  YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese”, J Proteome Res. 11(2):1118-3.

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