Institute of Physical Chemistry, PAS
Exploration of a non-invasive diagnostic method for Diabetic Retinopathy.
Development of a non-invasive diagnostic method for early detection of changes in the level of retinol binding protein 3 (RBP3) linked to Diabetic Retinopathy Life Sciences
vkaushik@ichf.edu.pl
A non-invasive diagnostic method for early detection of changes on the level of retinol binding protein 3 (RBP3) linked to Diabetic Retinopathy.
The research aims to get a higher resolution structure of the retinol binding protein 3 which is an essential protein in visual cycle. The major goal of the project is to propose a new diagnostic method in the field of Diabetic Retinopathy (DR). The current treatment methods for DR are invasive and lead to several post-treatment risks, i.e., mild loss of central vision, decreased ability to focus, etc. So, the demand for the proposed TPEF scenario is to introduce a technique for early diagnosis and a way to follow treatment efficacy in a non-invasive manner. Two-photon microscopy and detection/quantification of RBP3 at an early level could be a ray of hope in the development of new therapeutic approaches for Diabetic Retinopathy and many other ocular complications. The proposed method to detect the RBP3 protein in a non-invasive manner will address the current limitations of this field.
Vineeta Kaushik obtained her PhD in Biophysics from the University of Delhi South Campus, India, in 2020. She joined the ISB lab at ICTER in March 2021 as a postdoctoral fellow to work on the proteins involved in the visual cycle. Presently, she is working as an assistant professor under the PASIFIC Fellowship Programme at the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw.
Kaushik, V., Gessa, L., Kumar, N., Fernandes, H. (2023). Towards a new biomarker for Diabetic Retinopathy: exploring RBP3 structure and retinoids binding for functional imaging of eyes in vivo. Int. J. Mol. Sci. 24(5), 4408.
Kaushik, V., Prasad, S., & Goel, M. (2019). Biophysical and biochemical characterization of a thermostable archaeal cyclophilin from Methanobrevibacter ruminantium. International journal of biological macromolecules, 139, 139-152.
Kaushik, V., & Goel, M. (2021). Distribution of Peptidyl-Prolyl Isomerase (PPIase) in the Archaea. Frontiers in microbiology, 12.
44/52 Kasprzaka 01-224 Warszawa, Poland
Supervisor
Prof. Maciej Wojtkowski
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