Supervisors from Institute of Genetics and Animal Biotechnology

 a.bialek@igbzpan.pl

 a.bialek@ighz.pl

@ https://www.researchgate.net/profile/Agnieszka_Bialek

Agnieszka Białek holds a PhD in pharmaceutical sciences. She graduated from the Faculty of Pharmacy of the Medical University of Warsaw and postgraduate studies on “Scientific project management” at Gdynia Maritime University. Since October 2019 she has been working as an associate professor at the Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences (IGAB PAS). Her scientific interests are focused on the properties and mechanisms of action of conjugated fatty acids (CLA and CLnA isomers) in physiological and pathological conditions and their methods of analysis. She has revealed the influence of conjugated dienes and trienes of fatty acids in the diet on the risk of cancer, the mechanisms of their impact on lipid metabolism of the body and their connection with peroxidation. In preliminary cardio-oncological studies she has demonstrated the effect of diet supplementation conjugated fatty acids and selected plan materials on lipid metabolism in cardiac tissues during ongoing neoplastic process. She has been also interested in developmental programming, having established that proper maternal dietary intake of conjugated linoleic acids decreases mammary tumor risk in progeny. She is an expert for the National Centre for Research and Development and a member of the Polish Pharmaceutical Society, Polish Toxicological Society, and Polish Society of Nutritional Science.

 

Research interests:

Influence of bioactivie compounds in food on health; nutrigenomics; lipidomics; developmental programming; dietary supplements.

 

Major publications:

Białek A., Jelińska M., Białek M., Lepionka T., Czerwonka M., Czauderna M. (2020). “The effect of diet supplementation with pomegranate and bitter melon on lipidomic profile of serum and cancerous tissues of rats with mammary tumours”, Antioxidants; 9: 243; doi:10.3390/antiox9030243.

Białek A., Białek M., Lepionka T., Kaszperuk K., Banaszkiewicz T., Tokarz A. (2018). “The effect of pomegranate seed oil and grapeseed oil on cis‐9, trans‐11 CLA (rumenic acid), n‐3 and n‐6 fatty acids deposition in selected tissues of chickens”, Journal of Animal Physiology and Animal Nutrition ; 102(4): 962-976.

Białek A., Stawarska A., Bodecka J., Białek M., Tokarz A. (2017). “Pomegranate seed oil influences the fatty acids profile and reduces the activity of desaturases in livers of Sprague-Dawley rats”, Prostaglandins and Other Lipid Mediators; 131: 9-16.

Białek A., Zagrodzki P., Tokarz A. (2016). “Chemometric analysis of the interactions among different parameters describing health conditions, breast cancer risk and fatty acids profile in serum of rats supplemented with conjugated linoleic acids”, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA); 106: 1-10.

 i.camerlink@ighz.pl

@ http://www.ighz.pl/irene-camerlink-phd

Irene Camerlink is an assistant professor of animal behavior and welfare at the Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences. She earned her PhD from Wageningen University, the Netherlands, after which she spent 4 year as postdoctoral researcher at Scotland’s Rural College, Edinburgh UK, and 2 years at the University of Veterinary Medicine (Vetmeduni), Vienna, Austria. Her main research focusses on the behaviour and welfare of pigs.

 

Research interests:

Animal welfare, social behaviour, pigs, social bonds.

 

Major publications:

Camerlink I. (2020). Animal Welfare in Practice: Pigs (Ed.). Sheffield: 5m Publishing.

Camerlink I., et al. (2019). Royal Society Open Science 6(5), 181456.

Camerlink I., et al. (2018). Scientific Reports 8(1), 12116.

Camerlink I., Turner, S. P. (2017). Applied Animal Behaviour Science 192, 42-47.

Camerlink I., et al. (2016). Animal Behaviour 121, 71-78.

k.filimonow@ighz.pl

@ http://www.ighz.pl/en/dr-katarzyna-filimonow-1

Katarzyna Filimonow earned her PhD at University of Warsaw in 2015, at the Department of Embryology. Next (2016-2017) she held a postdoctoral fellowship at DanStem (the University of Copenhagen). Since 2017 she has been a postdoc at the Institute of Genetics and Animal Biotechnology PAS, in the Department of Experimental Biology, where she continues her research on lineage differentiation and epithelial-mesenchymal transition in mammalian embryo development.

 

Research interests:

Mammalian embryology, cell differentiation, EMT.

 

Major publications:

Filimonow K., Saiz N., Suwinska A., Wyszomirski T., Grabarek J.B., Ferretti E., Plusa B., Maleszewski M. (2018). “No evidence of involvement of E-Cadherin in cell fate specification and separation of Epi and PrE in mouse blastocyst”. PLOS One

Wigger M., Switon K. Filimonow K., Plusa B., Maleszewski M., Suwinska A. (2017). “Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway”, Sci Rep, Nov 9;(7):15136.

Krupa M., Mazur E., Szczepańska K., Filimonow K., Maleszewski M., Suwińska A. (2014). “Allocation of inner cells to epiblast vs primitive endoderm in the mouse embryo is biased but not determined by the round of asymmetric divisions (8→16- and 16→32-cells)”, Dev Biol, 385:136-48.

 a.piliszek@igbzpan.pl

@ http://a192.fsi.pl/en/dr-anna-piliszek-1

Anna Piliszek is an assistant professor and heads the Department of Experimental Embryology at the Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences (IGAB PAS) in Jastrzębiec. She began her adventure in developmental biology at the University of Warsaw, where she trained as an MSc student in the laboratory of Prof. A.K. Tarkowski. Next she earned her PhD degree from IGAB PAS under supervision of Prof. J. A. Modliński. She went on to complete a 4-year postdoctoral fellowship at the laboratory of Dr. Anna-Katerina Hadjantonakis at Sloan-Kettering Institute in New York. Her research focuses on the mechanisms of early lineage specification, exploring interspecific similarities and differences in preimplantation mammalian development.

 

Research interests:

Preimplantation development, lineage differentiation, epiblast, primitive endoderm, trophectoderm.

 

Major publications:

Piliszek A., Madeja Z.E. (2018). “Pre-implantation Development of Domestic Animals Current Topics in Developmental Biology 128, 267-294.

Piliszek A., Madeja Z.E., Plusa B. (2017). “Suppression of Erk signalling abolishes primitive endoderm formation but does not promote pluripotency in rabbit embryo”, Development 144, 3719-3730.

Kang M., Piliszek A., Artus J., Hadjantonakis A.K. (2013). “FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse”, Development 140, 267-79.

Płusa B.,  Piliszek A., Frankenberg S., Artus J., Hadjantonakis A.K. (2008).  “Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst”, Development 135, 3081-3091.

 s.sampino@ighz.pl

 samp_silv@live.it

@ https://www.researchgate.net/profile/Silvestre_Sampino

Silvestre Sampino earned his master’s degree in reproductive biotechnologies, then his PhD from the University of Teramo (Italy) in epidemiology and advanced diagnostic in comparative pathology. Since 2015 he has been an assistant professor at the Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences (IGAB PAS), where he has supervised a project financed by Poland’s National Science Centre (NCN). His research brings together his background in experimental embryology with a strong passion for neuroscience, by investigating the etiology and pathogenesis of neurodevelopmental disorders using mouse and sheep models. Moreover, Sampino is interested in developing biotechnological tools for the recovery and restoration of endangered/extinct mammalian species.

 

Research interests:

Reproductive biotechnologies, experimental embryology, brain development, behavioral neuroscience, animal models.

 

Major publications:

Saragusty J., Ajmone-Marsan P., Sampino S., Modlinski J.A., (2020). “Reproductive biotechnology and critically endangered species: merging in vitro gametogenesis with inner cell mass transfer”, Theriogenology. https://doi.org/10.1016/j.theriogenology.2020.06.009.

Sampino S., Juszczak G.R., Florek W., Barłowska K., Wojciechowska L., Horbańczuk K., Juszczak G.R., Modliński J.A., Sampino S. (2018). “Measuring perseverative behaviors in lambs (Ovis aries): position habit acquisition and reversal learning task in the V-detour and T-maze tests”, R.A Grant et al. (Eds.): Measuring Behavior, ISBN 978-1-910029-39-8, page 392-394.

Sampino S., Stankiewicz A.M., Zacchini F., Goscik J., Szostak A., Swiergiel A.H., Drago G., Modlinski J.A., Ptak G.E. (2017). “Pregnancy at Advanced Maternal Age Affects Behavior and Hippocampal Gene Expression in Mouse Offspring”, J Gerontol A Biol Sci Med Sci. Oct 12;72(11):1465-1473.
doi: 10.1093/gerona/glx016.

Zacchini F., Swiergiel A.H., Modlinski J.A., Loi P., Ptak G.E. (2014). “Grand-paternal age and the development of autism-like symptoms in mice progeny”, Transl Psychiatry. Apr 29;4(4):e386. doi: 10.1038/tp.2014.27.

Sampino S., Zacchini F., Swiergiel A.H., Modlinski A.J., Loi P., Ptak G.E. (2014). “Effects of blastomere biopsy on post-natal growth and behavior in mice”, Hum Reprod. Sep;29(9):1875-83.
doi: 10.1093/humrep/deu145.

 r.starzynski@ighz.pl

Rafał Starzyński has been the principal investigator on 5 research projects, and an investigator participating in 11. The scope of his scientific interests and research field is broad, but always centers around the systemic regulation of iron metabolism. This includes the following topics:

  • the molecular background of mammalian cell susceptibility to oxidative stress and its relationship to iron metabolism;
  • the regulation of cellular iron metabolism by nitric oxide;
  • the interaction between oxidative stress and systemic iron metabolism;
  • the molecular mechanisms of iron absorption in piglets and the role of hepcidin;
  • correction of iron deficiency anemia in newborn domestic pigs based on innovative procedures of iron supplementation with novel iron preparations;
  • the role of copper transporters in the regulation of iron metabolism in mice at various periods of postnatal development;
  • the molecular basis of interaction between copper and iron metabolism;
  • iron deficiency anemia during pregnancy, premature babies and in the postpartum period.

 

Research interests:

Iron metabolism, oxidative stress, iron deficiency anemia, iron supplementation.

 

Major publications:

Mazgaj R., Szudzik M., Lipiński P., Jończy A., Smuda E., Kamyczek M., Cieślak B., Swinkels D., and

Starzyński R.R. (2020).  “Effect of orally administered sucrosomial ferric pyrophosphate (SFP) and

iron sulphate (FeSO4) to healthy sows during gestation on maternal iron status and piglets

outcome”, Animals.

Bednarz A., Lipiński P., Starzyński R.R.,., Tomczyk M., Nowak W., Mucha O., Ogórek M., Pierzchała

O., Jończy A., Staroń R., Śmierzchalska J., Rajfur Z., Baster Z., Józkowicz A., Lenartowicz M. (2019).

“Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice”,

Scientific Report, 2019 Jul 31;9(1):11102. doi: 10.1038/s41598–019–47414–y.

Szudzik M., Lipiński P., Jończy A., Mazgaj R., Pieszka M., Kamyczek M., Smuda E., Starzyński R.R.

(2019). “Long-term effect of split iron dextran/hemoglobin supplementation on erythrocyte and

iron status, growth performance, carcass parameters and meat quality of Polish Large White and

990 line pigs”, Biological Trace Element Research, DOI: 10.1007/s12011–019–01950–w.

Lenartowicz M., Ogorek M., Sylwia Herman S., Pierzchala O., Bednarz A., Rajfur Z., Baster Z., Grzmil

P., Starzyński R.R., Szudzik M., Jonczy J., Lipinski P. (2018). “Molecular machinery providing copper

bioavailability for spermatozoa along the epididymial tubule in mouse”, Biology of Reproduction,

2018–0291R1.

Staroń R., Lipiński P., Lenartowicz M., Bednarz A., Gajowiak A., Smuda E., Krzeptowski W., Pieszka

M., Korolonek T., Hamza I., Swinkels D.W., Van Swelm R.P.L., Starzyński R.R. (2017). “Dietary

hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile

of genes involved in heme iron absorption”, PLoS One, 2017 Jul 13;12(7):e0181117.

 l.szymanski@igbzpan.pl

@ ORCID: https://orcid.org/0000-0003-0148-541X

Łukasz Szymański earned his PhD in medical sciences at the age of 25 from the Military Institute of Hygiene and Epidemiology, investigating the Fas/FasL dependent signaling pathway in atopic dermatitis. Next he became deputy head of the Department of Microwave Safety and head of the Interdepartmental GLP Laboratory. He held fellowships at the Institute of Genetics and Development in Rennes, France with Prof. Jacek Kubiak and at the Translational Vectorology, Vector and Genome Engineering Facility, Children’s Medical Research Institute, Sydney, Australia with Prof. Leszek Lisowski. In 2016 he also started working at Konmex BioLabs, where he is an R&D manager. His scientifics interests are mainly focused on cancer, immunology and bioengineering.

 

Research interests:

Immunology, cancer, stem cells, bioengineering, leukemia.

 

Major publications:

Szymański Ł., Jęderka K., Cios A., Ciepelak M., Lewicka A., Stankiewicz W., Lewicki S. (2020). “A Simple Method for the Production of Human Skin Equivalent in 3D”, Multi-Cell Culture. Int. J. Mol. Sci., 21, 4644.

Szymański Ł., Cios A., Lewicki S., Szymanski P., Stankiewicz W. (2018). “Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis – Manipulation by the electromagnetic field”, PLoS ONE 13(10): e0205103.

Szymański Ł., Sobiczewska E., Cios A., Szymanski P., Ciepielak M., Stankiewicz W. (2020). “Immunotropic effects in cultured human blood mononuclear cells exposed to a 900 MHz pulse-modulated microwave field”, Journal of Radiation Research, Vol. 61, Issue 1,  Pag. 27–33.

 h.taniguchi@ighz.pl

@ https://hiroataniguchi.wixsite.com/polska-epigenetics

Hioraki Taniguchi, originally from Japan, earned his PhD from Laval University (Canada) in 2007. After training at several research institutes (McGill University Goodman Cancer Center, Riken Brain Science Institute), he was as an assistant professor (2012-2014) at Doshisha University (Kyoto, Japan). He is currently an associate professor at the Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences (leader of the Team for Genome Editing and Transcriptional Regulation). He collaborates with researchers from various countries (Japan, China, Bangladesh, India, England, Germany, United States, and Canada). His work focuses on the role of transcriptional regulation in cell fate decision in the field of cancer biology and neuroscience.

 

Research interests:

CRISPR, genome editing, transcriptional regulation, cancer, neuronal differentiation.

 

Major publications:

Taniguchi H., Fujimoto A., Kono H., Furuta M., Fujita M., Nakagawa H. (2018). “Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer”,  Oncotarget. 9(40):26144-26156. doi: 10.18632/oncotarget.25456.

Taniguchi H., Okamuro S., Kohji M., Waku T., Kubo K., Hatanaka A., Sun Y., Chowdhury A.M., Fukamizu A., Kobayashi A. (2017). “Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes”, Biochem.Biophys.Res.Commun. 11. pii: S0006-291X (17) 30047-5. doi: 10.1016/ j.bbrc.2017.01.038.

Fujimoto A., Furuta M., Totoki Y., Tsunoda T., Kato M., Shiraishi Y., Tanaka H., Taniguchi H., et al. (2016). “Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer”, Nat.Genet. 48: 500-509.

Nakagawa H., Wardell C.P., Furuta M., Taniguchi H., Fujimoto A. (2015). “Cancer whole-genome sequencing: present and future”, Oncogene. ; 34: 5943-5950.

Endo K., Taniguchi H., Karim M.R., Krejci A., Kinameri E., Siebert M., Ito K., Bray S.J., Moore A.W. (2012). “Chromatin modification of Notch targets in olfactory receptor neuron diversification”, Nat.Neurosci. ; 15: 224-233.

 a.zelent@ighz.pl

 azelent7@gmail.com

@ https://www.researchgate.net/profile/Arthur_Zelent

@ https://www.scopus.com/authid/detail.uri?authorId=7006566218

@ https://orcid.org/0000-0002-7968-9888

Artur Zelent is an established researcher with a very strong background in nuclear receptor signaling and cancer epigenetics. His work on Acute Promyelocytic Leukemia (APL) and Acute Myeloid Leukemia in general has brought him international recognition, as reflected in the number and quality of his publications, doctoral students, scope of funding and international activities at conferences, site visits and student examinations. He moved to Poland in 2018, and after a short tenure at the Military Institute of Hygiene and Epidemiology he took up employment at the Institute of Genetics and Animal Breading, Polish Academy of Sciences (IGAB PAS), with the aim of establishing a truly translational laboratory and collaborating closely with medically trained individuals, such as hematologist-oncologists as well as other cancer focused specialists. He continues to investigate the genetic and epigenetic mechanisms that underlie the deregulation of gene expression, and particularly retinoic acid signaling in human acute leukemia and cancer in general.

He has authored over 200 publications, 116 of them published in international peer-reviewed journals. His total number of citations 9868, with H = 51 according to the Scopus database.

 

Research interests:

Cancer, genetics and molecular biology, medicine, immunology.

 

Major publications:

Zelenet A. (2017).Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia”, Nature Medicine, 23(1):69-78.

Zelenet A. (2012).Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia”, Nature Medicine, 18:605-611.

Zelenet A. (2007).Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF”, Science, 316:860-866.

Zelenet A. (2005). “Role of the proto-oncogene Pokemon in cellular transformation and ARF repression”, Nature, 435:278-285.

Zelenet A. (1989). “Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin”, Nature, 339:714-717.

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