Jadwiga Jaruzelska is a professor and group leader at the Department of Nucleic Acids, Institute of Human Genetics, Polish Academy of Sciences (IHG PAS) in Poznań, Poland. Her research is focused on certain aspects of regulation of gene expression in germ cells, in the context of male infertility.
She was a research fellow at the German Cancer Center, Heidelberg, Germany (1983-1985) and at Unitè de Recherches sur les Handicaps Génètiques de l' Enfant, INSERM U-12,Hôpital des Enfants Malades, Paris, and Centre de Génètique Moleculaire, CNRS Gif sur Yvette, France (1991-1993). In 1998-2001 she was a visiting professor at the University of California at San Francisco, San Francisco, USA. She has spent sabbaticals at Université de Montréal Centre de Cancérologie Charles Bruneau, Hôpital, Sainte Justine, Montréal, Canada (1996, 3 months), at Massachusetts Institute of Technology, Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Cambridge, MA, USA (1997, 1998, 2 months), University of California at San Francisco (UCSF), Department of Obstetrics, Gynecology and Reproductive Sciences San Francisco CA, USA (1998-2000), and University of California at San Francisco (UCSF) Department of Obstetrics, Gynecology and Reproductive Sciences San Francisco CA, USA (2001, 5 months).
She has received numerous honors and awards, including a fellowship from Deutscher Akademischer Austauschdienst, Germany 1983-1985; a fellowship from the French Government (Ministère de la Recherche et de la Technologie MRT) 1991-1993; “Established Scientist Award” from the European Society of Human Reproduction and Embryology at the annual meeting, Vienna, Austria 2002; an the award from the Polish Society of Genetics for the best paper published in Poland in the field of human genetics in 2013.
Posttranslational gene regulation, RNA-binding proteins, microRNAs, germ cells, human sex determination, disorders of sex development
Śmiałek MJ, Ilaslan E, Sajek MP, Świercz A, Janecki DM, Kusz-Zamelczyk K, Woźniak T, Kotecki M, Handschuh L, Figlerowicz M, Jaruzelska J. “Characterization of RNP networks of PUM1 and PUM2 post-transcriptional regulators in TCam-2 cells, a human male germ cell model”. Cells, 2020 Apr 16, 9 (4): 984, doi: 10.3390/cells9040984.
Śmialek MJ, Kuczyńska B, Ilaslan E, Janecki DM, Sajek MP, Kusz-Zamelczyk K, Jaruzelska J. “Kinesin KIF18A is a novel PUM- regulated target promoting mitotic progression and survival of human male germ cell line”. Journal of Cell Science, 2020, 133 jcs240986, 8 stron, doi: 10.1242/jcs.240986 Epub 2020 Mar 24.
Sajek M, Janecki DM, Śmiałek MJ, Ginter-Matuszewska B, Spik A, Oczkowski S, Ilaslan E, Kusz-Zamelczyk K, Kotecki M, Blazewicz J, Jaruzelska J “PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues”. Cell Mol Life Sci, 2019, 76 (1): 147-161.
Janecki DM, Sajek M, Śmiałek MJ, Kotecki M, Ginter-Matuszewska B, Kuczyńska B, Spik A, Kolanowski T, Katazawa R, Kurpisz M, Jaruzelska J “SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminoma”. Oncotarget, 2018 9 (65): 32466-77.
Calvel P, Kusz-Zamelczyk K, Makrythanasis P, Janecki D, Borel C, Conne B, Vannier A, Béna F, Gimelli S, Fichna P, Antonarakis SE, Nef S, Jaruzelska J “A Case of Wiedemann-Steiner Syndrome Associated with a 46,XY Disorder of Sexual Development and Gonadal Dysgenesis”. Sex Dev, 2015, 9 (5): 289-295.
Ryszard Slomski is a professor at the Institute of Human Genetics, Polish Academy of Sciences (IHG PAS) in Poznan, where he serves as deputy director for research. For years he has held the position of professor and headed the Department of Biochemistry and Biotechnology of Poznań University of Life Sciences, Poland. Born in 1950, he earned his MSc in the biochemistry of nucleic acids in 1974 at Adam Mickiewicz University in Poznan, his Ph.D. in human genetics and his DSc (habilitation) at the Marcinkowski Medical Academy, Poznan, in 1976 and 1982; and became a professor of medical sciences, Polish Academy of Sciences, in 1990.
Main scientific achievements are: 1) characterization of mouse thymus leukemia antigens; 2) implementation of DNA tests for disease diagnostics; 3) introducing individual genetic identification in Poland based on DNA analysis; 4) implementation and propagation of in vitro amplification of DNA in Poland (PCR); 5) obtaining transgenic animals for biomedical needs.
He has authored/co-authored over 400 publications, including 19 monographs, 343 original research articles, 109 review articles, 416 GenBank annotations. His total IF is 416.882, Hirsch index 20, sum of times cited 1428. He has published 230 articles in international journals and 113 articles in Polish journals. The co-author of 14 patent applications and 1 implemented technology.
Molecular genetics and biotechnology connected to biomedicine.
Podralska M, Ciesielska S, Kluiver J, van den Berg A, Dzikiewicz-Krawczyk A, Slezak-Prochazka I. “Non-Coding RNAs in Cancer Radiosensitivity: MicroRNAs and lncRNAs as Regulators of Radiation-Induced Signaling Pathways”. Cancers, 12(6), 1662, 2020.
Krela-Kaźmierczak I, Skrzypczak-Zielińska M, Kaczmarek-Ryś M, Michalak M, Szymczak-Tomczak A, Hryhorowicz S, Szalata M, Łykowska-Szuber L, Eder P, Stawczyk-Eder K, Tomczak M, Słomski R, Dobrowolska D. “The ESR1 gene variants are predictive of osteoporosis in female patients with Crohn's disease”. J Clin Med, 8(9). pii: E1306, 2019.
Hryhorowicz S, Kaczmarek-Ryś M, Andrzejewska A, Staszak K, Hryhorowicz M, Korcz A, Słomski R. “Allosteric Modulation of Cannabinoid Receptor 1 – Current Challenges and Future Opportunities”. Int. J. Mol. Sci. 20, 5874, 2019.
Kaczmarek-Ryś M, Ziemnicka K, Pławski A, Budny B, Michalak M, Hryhorowicz S, Hoppe-Gołębiewska J, Boruń P, Gołąb M, Czetwertyńska M, Sromek M, Szalata M, Ruchała M, Słomski R. “Modifying impact of RET gene haplotypes on medullary thyroid carcinoma clinical course”. Endocr Relat Cancer. 25(4):421-436, 2018.
Woźniak A, Grześkowiak BF, Babayevska N, Zalewski T, Drobna M, Woźniak-Budych M, Wiweger M, Słomski R, Jurga S. “ZnO@Gd2O3 core/shell nanoparticles for biomedical applications: Physicochemical, in vitro and in vivo characterization”. Mater Sci Eng C Mater Biol Appl. 80, 603-615, 2017.
Kwiatkowska J, Wigowska-Sowinska J, Napierala D, Slomski R, Kwiatkowski DJ. “Mosaicism in tuberous sclerosis as a potential cause of the failure of molecular diagnosis”. N Engl J Med. 340(9), 703-707, 1999.
Agnieszka Dzikiewicz-Krawczyk earned her PhD in 2012 from the Institute of Human Genetics, Polish Academy of Sciences (IHG PAS) for studying the functional impact of heterozygous mutations in the NBN gene, which encodes a protein involved in DNA double-strand break repair. She then moved on to study the non-coding RNAs in hematological malignancies. In 2015-2016 she spent 2 years as a postdoctoral fellow at the University Medical Center Groningen, the Netherlands. Since 2019 she has led the Independent Research Group of Non-Coding Genome Function. Currently, the Group is implementing three research projects which aim to functionally characterize various non-coding sequences in the genome (miRNA, lncRNA, eRNA, enhancers, promoters and transcription factor binding sites) in basic cellular processes and in cancer pathogenesis (http://igcz.poznan.pl/en/structure/independent-research-groups/).
Non-coding genome, non-coding RNA, MYC, cancer, DNA repair
Dzikiewicz-Krawczyk A. et al. “ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma”. Leukemia 2017.
Dzikiewicz-Krawczyk A. et al. “Argonaute 2 RNA Immunoprecipitation Reveals Distinct miRNA Targetomes of Primary Burkitt Lymphoma Tumors and Normal B Cells”. Am J Pathol 2018.
Swier LJYM, Dzikiewicz-Krawczyk A. et al. “Intricate crosstalk between MYC and non-coding RNAs regulates hallmarks of cancer”. Mol Oncol 2019.
Niu F., Kazimierska M., …, Dzikiewicz-Krawczyk A., Kluiver J. “The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth”. Cancers 2020.
Podralska M., …, Dzikiewicz-Krawczyk A., Slezak-Prochazka I. “Non-Coding RNAs in Cancer Radiosensitivity: MicroRNAs and lncRNAs as Regulators of Radiation-Induced Signaling Pathways”. Cancers 2020.
Maciej Giefing is a cancer geneticist at the Institute of Human Genetics, Polish Academy of Sciences (IHG PAS). He became interested in cancer genetics during his PhD studies and initiated an ongoing collaboration with German research groups from the German Hodgkin Study Group that resulted in an international PhD (promoters: Siebert R, Szyfter K.) that he defended at IHG PAS in 2008. He has since then continued his research on cancer genetics, spending three years in a post-doc position at the Institute of Human Genetics, Christian Albrecht’s University in Kiel (Germany) focusing on the genetics of classical Hodgkin Lymphoma. After returning to Poland he earned his DSc (habilitation) degree in 2014 for a series of publications entitled “Identification of genes related to classical Hodgkin lymphoma pathogenesis”. In 2015 he became head of the Department of Cancer Genetics at the Institute of Human Genetics in Poznań, where we research the genome and epigenome of cancer cells.
He has published more than 50 scientific articles with a cumulative Impact Factor > 200 (with > 1200 citations), including in such prestigious journals as Nature Medicine, PNAS, Blood, Leukemia and the European Journal of Cancer.
Cancer genetics, classical Hodgkin lymphoma, head and neck cancer, epigenetics
Kostrzewska-Poczekaj M, Byzia E, Soloch N, Jarmuz-Szymczak M, Janiszewska J, Kowal E, Paczkowska J, Kiwerska K, Wierzbicka M, Bartochowska A, Ustaszewski A, Greczka G, Grenman R, Szyfter K and Giefing M. “DIAPH2 alterations increase cellular motility and may contribute to the metastatic potential of laryngeal squamous cell carcinoma”. Carcinogenesis. 2019; 40:1251-1259.
Paczkowska J, Soloch N, Bodnar M, Kiwerska K, Janiszewska J, Vogt J, Domanowska E, Martin-Subero JI, Ammerpohl O, Klapper W, Marszalek A, Siebert R, Giefing M. “Expression of ELF1, a lymphoid ETS domain containing transcription factor, is recurrently lost in classical Hodgkin lymphoma”. British Journal of Haematology. 2019; 185:79-88.
Lamprecht B, Walter K, Kreher S, Kumar R, Hummel M, Lenze D, Köchert K, Bouhlel MA, Richter J, Soler E, Stadhouders R, Jöhrens K, Callen D, Harte MF, Giefing M, Barlow R, Stein H, Anagnostopoulos I, Janz M, Cockerill P, Siebert R, Dörken B, Bonifer C, Mathas S. “Activation of the CSF1R proto-oncogene by long terminal repeat derepression in human malignancies”. Nature Medicine 2010; 16: 571-579.
Schmitz R, Hansmann M-L, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R and Küppers R. “TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma”. The Journal of Experimental Medicine 2009; 206: 981-989.
Natalia Rozwadowska is a stem cell biologist. Since 2018 she has headed the Department of Molecular Pathology at the Institute of Human Genetics, Polish Academy of Sciences (IHG PAS). She earned her PhD from the Poznan University of Medical Science, where her PhD work was focused on the expression of different genes during spermatogenesis, especially in relation to infertility. As a postdoctoral fellow her interests shifted to the biology of muscle progenitor cells and their potential both in basic research (skeletal muscle differentiation) and translational research (myoblast transplantation as a therapy for heart infraction). It is perhaps this combination of diverse backgrounds that led her to develop an interest in the emerging field of pluripotent stem cell biology, particularly of disease modeling (e.g. cardiomyopathy, infertility) and future clinical application. She has authored numerous publications and been honored with several awards, including the Prime Minister’s Awards for Outstanding PhD and DSc Achievements. She currently serves as PI on three scientific projects and is involved in close interdisciplinary scientific collaboration as well as collaboration with the business environment.
RNA binding proteins, stem cell differentiation, spermatogenesis, cardiogensis, translational medicine,
Fiedorowicz K*, Rozwadowska N*, Zimna A, Malcher A, Tutak K, Szczerbal I, Nowicka-Bauer K, Nowaczyk M, Kolanowski TJ, Łabędź W, Kubaszewski Ł, Kurpisz M “Tissue-specific promoter-based reporter system for monitoring cell differentiation from iPSCs to cardiomyocytes”. Sci Rep. 2020 Feb 5;10(1):1895. doi: 10.1038/s41598-020-58050-2.
Li J, Rozwadowska N, Clark A, Fil D, Napierala JS, Napierala M. “Excision of the expanded GAA repeats corrects cardiomyopathy phenotypes of iPSC-derived Friedreich's ataxia cardiomyocytes”. Stem Cell Res. 2019 Oct;40:101529. doi: 10.1016/j.scr.2019.101529.
Lewandowski J, Rozwadowska N, Kolanowski TJ, Malcher A, Zimna A, Rugowska A, Fiedorowicz K, Łabędź W, Kubaszewski Ł, Chojnacka K, Bednarek-Rajewska K, Majewski P, Kurpisz M “The impact of in vitro cell culture duration on the maturation of human cardiomyocytes derived from induced pluripotent stem cells of myogenic origin”. Cell Transplant. 2018 Jul;27(7):1047-1067. doi: 10.1177/0963689718779346.
Gwizdala A, Rozwadowska N, Kolanowski TJ, Malcher A, Cieplucha A, Perek B, Seniuk W, Straburzynska-Migaj E, Oko-Sarnowska Z, Cholewinski W, Michalak M, Grajek S, Kurpisz M. “Safety, feasibility and effectiveness of first in-human administration of muscle-derived stem/progenitor cells modified with connexin-43 gene for treatment of advanced chronic heart failure”. Eur J Heart Fail. 2017 Jan;19(1):148-157. doi: 10.1002/ejhf.700.
Malcher A, Rozwadowska N, Stokowy T, Kolanowski T, Jedrzejczak P, Zietkowiak W, Kurpisz MPotential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis. Fertil Steril. 2013 Dec;100(6):1686-94.e1-7. doi: 10.1016/j.fertnstert.2013.07.1999.
Rozwadowska N, Kolanowski T, Wiland E, Siatkowski M, Pawlak P, Malcher A, Mietkiewski T, Olszewska M, Kurpisz M. Characterisation of nuclear architectural alterations during in vitro differentiation of human stem cells of myogenic origin. PLoS One. 2013 Sep 3;8(9):e73231.