arkadiusz.miazek@hirszfeld.pl

@ https://orcid.org/0000-0002-7210-2706

Arkadiusz Miążęk obtained his PhD in biochemistry from Wroclaw University (Poland) after completing doctoral studies at the Basel Institute for Immunology (Switzerland). From 1997 to 2003 he was a postdoctoral researcher at Centre d’Immunologie de Marseille Luminy (France). From 2011 he is the head of the Laboratory of Tumor Immunology at the Hirszfeld Institute of Immunology. His notable achievements include characterization of signaling cues associated with positive selection of T cells in the thymus, association of limited protein degradation of adaptor molecules (i.e. LAT) as early markers of cellular apoptosis and T-cell anergy, development of novel monoclonal antibodies for use in diagnosis and experimental therapy of hematological malignancies.

Research interests:

Immune tolerance, T-cell development and signaling, tumor immunology.

Recent publications:

Lisowska M., Milczarek M., Ciekot J., Kutkowska J., Hildebrand W., Rapak A., Miazek A. (2019). “An Antibody Specific for the Dog Leukocyte Antigen DR (DLA-DR) and Its Novel Methotrexate Conjugate Inhibit the Growth of Canine B Cell Lymphoma”, Cancers (Basel). 26;11(10):1438. (IF=6.02) doi: 10.3390/cancers11101438.

Lisowska M., Pawlak A., Kutkowska J., Hildebrand W., Ugorski M., Rapak A., Miazek A. (2018). “Development of novel monoclonal antibodies to dog leukocyte antigen DR displaying direct and immune-mediated cytotoxicity toward canine lymphoma cell lines”, Hematol Oncol. 24. doi: 10.1002/hon.2507 (IF=3.11) doi: 10.1002/hon.2507.

Arbulo-Echevarria M.M., Narbona-Sánchez I., Fernandez-Ponce C.M., Vico-Barranco I., Rueda-Ygueravide M.D., Dustin M.L., Miazek A., Duran-Ruiz M.C., García-Cózar F., Aguado E.A. (2018). “Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling”, Front Immunol. 2;9:115. doi: 10.3389/fimmu.2018.00115. eCollection 2018. (IF=6.42) doi: 10.3389/fimmu.2018.00115. eCollection 2018.

Scirka B., Szurek E., Pietrzak M., Rempala G., Kisielow P., Ignatowicz L., Miazek A. (2017). “Anti-GITR Antibody Treatment Increases TCR Repertoire Diversity of Regulatory but not Effector T Cells Engaged in the Immune Response against B16 Melanoma”, Arch Immunol Ther Exp;65(6):553-564. doi: 10.1007/s00005-017-0479-1 (IF=2.82) doi: 10.1007/s00005-017-0479-1.

Marek-Bukowiec K., Aguado E., Miazek A. (2016). “Phorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription”, Genes Immun;17(5):313-20 (IF=2.52) doi: 10.1038/gene.2016.25.

 jolanta.lukasiewicz@hirszfeld.pl

Jolanta Łukasiewicz (ORCID ID 0000-0001-8081-7261) is a professor at the Hirszfeld Institute with over 20 years of experience in microbiology and immunochemistry. She leads the Laboratory of Microbial Immunochemistry and Vaccines at the Hirszfeld Institute. She earned her MSc in biotechnology at the Wrocław University of Science and Technology in 1997. Her expertise covers the structural analysis of bacterial carbohydrate antigens, particularly LPS, and studies on LPS structure and biological activity relationships (immunogenicity, toxicity, immune system activation, vaccine development). The laboratory is well equipped with key research infrastructure for functional studies and preparative and analytical chemistry of carbohydrates, i.e.: NMR spectroscopy including HR-MAS NMR and STD-NMR, ESI-MS and MALDI-TOF mass spectrometry, and surface plasmon resonance (Biacore T200). The research at the laboratory, mostly funded by external sources, is conducted by an experienced team in close collaboration with immunologists, epidemiologists, and bioinformaticians. Her main achievements include: (i) identification of a covalent linkage between enterobacterial common antigen (ECA) and LPS in Shigella sonnei (ECA_LPS); (ii) characteristics of interactions between human complement system (MBL and ficolin-3) with Gram-negative bacteria LPS; (iii) Identification of new structural modifications that determine the diversity of Klebsiella pneumoniae O1, O2, and O3 O-antigens relevant for the development of therapeutic monoclonal antibodies.

Research interests:

Carbohydrate antigens; glycolipids; lipopolysaccharide; neoglycoconjugate vaccines; NMR, mass spectrometry, SPR applications in structural glycomics.

Major publications:

Rollenske T., Szijarto V., Lukasiewicz J., Guachalla L.M., Stojkovic K., Hartl K., Stulik L., Kocher S., Lasitschka F., Al-Saeedi M., Schröder-Braunstein J., Von Frankenberg M., Gaebelein G., Hoffmann P., Klein S., Heeg K., Nagy E., Nagy G., Wardemann H. (2018). “Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen”, Nature Immunology, 19: 617–624.

Man-Kupisinska A., Swierzko A.S., Maciejewska A., Hoc M., Rozalski A., Siwinska M., Lugowski C., Cedzynski M., Lukasiewicz J. (2018). “Interaction of Mannose-Binding Lectin with Lipopolysaccharide Outer Core Region and Its Biological Consequences”, Front Immunol, 9:1498.

Guachalla M., Stojkovic K., Hartl K., Kaszowska M., Kumar Y., Wahl B., Paprotka T., Nagy E., Lukasiewicz J., Nagy G., Szijártó V. (2017). “Discovery of monoclonal antibodies cross-reactive to novel subserotypes of K. pneumoniae O3”, Scientific Reports, 7:6635.

Stojkovic K., Szijártó V., Kaszowska M., Niedziela T., Hartl K., Nagy G., Lukasiewicz J. (2017). “Identification of d-Galactan-III As Part of the Lipopolysaccharide of Klebsiella pneumoniae Serotype O1”, Front Microbiol, 8:684.

Man-Kupisinska A., Michalski M., Maciejewska A., Swierzko A.S., Cedzynski M., Lugowski C., Lukasiewicz J.  (2016). “A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins”, PLoS One, 11(5):e0156691.

 katarzyna.bogunia-kubik@hirszfeld.pl

Katarzyna Bogunia-Kubik is a professor of biological sciences (immunology, immunogenetics) with over 20 years of experience in immunogenetics. Her research focuses on transplant immunology/immunogenetics and searching for new markers related to disease susceptibility, course, and response to treatment (e.g. rheumatic or haematological disorders), assessment of therapy effectiveness and safety, and analysis of issues related to immunogenetics of ageing. The main aspects of her work are HLA and non-HLA polymorphisms studies, and expression of miRNA and other genes coding for proteins involved in regulation of immune response.

She has served as president of the Polish Society for Immunogenetics, and is now a member of its board. She is also a member of European Federation for Immunogenetics (EFI). She has received the European Specialisation in Histocompatibility & Immunogenetics (ESHI) Honorary Diploma, is a member of the EFI External Proficiency Testing Committee, EFI Councillor and a representative of Poland on the European Board of Transplant Immunology (EBTI).

Research interests:

Immunology/immunogenetics, diagnostic and prognostic biomarkers, regulation of immune response, transplantation, rheumatology, hematooncology.

Major publications:

Bogunia-Kubik K. (2020). Pharmacogenomics J.

Bogunia-Kubik K. (2020). Scientific Reports.

Bogunia-Kubik K. (2019, 2015). Cytokine.

Bogunia-Kubik K. (2017, 2015, 2006). Br J Haematol.

Bogunia-Kubik K. (2017). Eur J Clin Invest.

Bogunia-Kubik K. (2017). Int J Mol Sci.

Bogunia-Kubik K. (2016, 2015). Joint Bone Spine.

Bogunia-Kubik K. (2015). J Pharmaceut Biomed Analysis.

Bogunia-Kubik K. (2009, 2005). Bone Marrow Transplant.

Bogunia-Kubik K. (2011, 2015, 2016, 2018). Arch Immunol Ther Exp.

lidia.karabon@hirszfeld.pl

Lidia Karabon is an associate professor at the Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, in Wrocław (IITD PAS). She earned her master’s degree in chemistry at the Wrocław University of Technology in 1985, then defended her doctoral thesis in 2003 at IITD, and earned her DSc (habilitation) degree in 2012. Starting in 1991, she joined the team of Prof. Lange at the Lower Silesian Center for Cell Transplantation with the National Register of Bone Marrow Donors in Wrocław, where in 2001–2004 she was the head of the HLA Laboratory. In 2004–2005 she was visiting scholar in the laboratory of Prof. Alana Gewirtz at the Pennsylvania University Medical School. She became employed at IITD PAS in 2006, in Prof. Frydecka’s Laboratory. Recently, Lidia Karabon became the head of the Laboratory of Genetics and Epigenetics of Human Diseases.

Research interests:

Genetic and epigenetics of immune check-points molecules, biomarkers of outcome of graft versus host disease after hematopoietic cells transplantation, disease association study in regard to genetic polymorphisms in neoplastic and autoimmune diseases.

Major publications:

Karabon L., Partyka A., Jasek M., Lech-Maranda E., Grzybowska-Izydorczyk O., Bojarska-Junak A., Pawlak-Adamska E., Tomkiewicz A., Robak T., Rolinski J., Frydecka I. (2016). “Intragenic Variations in BTLA Gene Influence mRNA Expression of BTLA Gene in Chronic Lymphocytic Leukemia Patients and Confer Susceptibility to Chronic Lymphocytic Leukemia”, Arch Immunol Ther Exp (Warsz). Dec; 64:137-145. doi: 10.1007/s00005-016-0430.

Karabon L., Tupikowski K., Tomkiewicz A., Partyka A., Pawlak-Adamska E., Wojciechowski A., Kolodziej A., Dembowski J., Zdrojowy R., Frydecka I. (2017). “Is the Genetic Background of Co-Stimulatory CD28/CTLA-4 Pathway the Risk Factor for Prostate Cancer?”, Pathol Oncol Res.;23(4):837-843. doi: 10.1007/s12253-016-0180-4.

Partyka A., Tupikowski K., Kolodziej A., Zdrojowy R., Halon A., Malkiewicz B., Dembowski J., Frydecka I., Karabon L. (2016). “Association of 3' nearby gene BTLA polymorphisms with the risk of renal cell carcinoma in the Polish population”, Urol Oncol.;34(9):419.e13-9.

Karabon L., Markiewicz M., Chrobot K., Dzierzak-Mietla M., Pawlak-Adamska E., Partyka A., Koclega A., Kyrcz-Krzemien S., Frydecka I. (2018). “The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation”, J Immunol Res. 7;2018:3826989. doi: 10.1155/2018/3826989.

Karabon L., Partyka A., Ciszak L., Pawlak-Adamska E., Tomkiewicz A., Bojarska-Junak A., Roliński J., Wołowiec D., Frydecka I., Kosmaczewska A. (2020). “Abnormal expression of BTLA and CTLA-4 immune checkpoints molecules in chronic lymphocytic leukeamia patients”, J. Immunol. Res.  in press 2020.

marcin.czerwinski@hirszfeld.pl

@ https://www.researchgate.net/profile/Marcin_Czerwinski

@ https://twitter.com/CzerwinsMarcin

Marcin Czerwiński graduated from the Department of Chemistry, Technical Univeristy of Wrocław in 1983. He earned his PhD from the Hirszfeld Institute of Immunology and Experimental Therapy in 1991. After 3 years of postdoctoral fellowship at Prof. Steven L. Spitalnik’s lab (University of Pennsylvania School of Medicine) he has pursued a career in the field of glycobiology and became a full professor in 2016. At present, he leads the Laboratory of Glycobiology at the Department of Immunochemistry.

Research interests:

Glycobiology, immunochemistry, blood group antigens.

Major publications:

Mikolajczyk M., Kaczmarek R., Czerwinski M. (2020). “How glycosylation affects glycosylation: the role of N-glycans in glycosyltransferase activity”, Glycobiology,  cwaa041, https://doi.org/10.1093/glycob/cwaa041.

Kaczmarek R., Szymczak-Kulus K., Bereźnicka A., Mikołajczyk K., Duk M., Majorczyk E., Krop-Watorek A., Klausa E., Skowrońska J., Michalewska B., Brojer E., Czerwinski M. (2018). “Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system”, PLoS One., 13(4):e0196627. doi: 10.1371/journal.pone.0196627.

Kaczmarek R., Duk M., Szymczak K., Korchagina E., Tyborowska J., Mikolajczyk K., Bovin N., Szewczyk B., Jaskiewicz E., Czerwinski M. (2016). “Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR blood group antigens”, Biochem Biophys Res Commun., 29;470(1):168-74.

Kaczmarek R., Buczkowska A., Mikolajewicz K., Krotkiewski H., Czerwinski M. (2014). “P1PK, GLOB, FORS blood group systems and GLOB collection: biochemic and clinical aspects. Do we understand it all yet?”, Transf. Med. Rev., 28, 126-136.

Suchanowska A., Kaczmarek R., Łukasiewicz J., Smolarek D., Majorczyk E., Laskowska A., Jaśkiewicz E., Waśniowska K., Grodecka M., Lisowska E., Czerwiński M. (2012). “A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome”, J. Biol. Chem., 287: 38220-38230.

 mariola.pasciak@hirszfeld.pl

@ https://www.researchgate.net/profile/Pasciak_Mariola

Mariola Pasciak began her research experience as a research assistant in 1993 at the Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (IIET PAS), in the Department of Immunology of Infectious Diseases. Since 2015 she has been an associate professor at IIET PAS, in the Laboratory of Medical Microbiology. From 2000 to 2010 she spent numerous monthly research stays at the Biomedical Research Center in Borstel, Germany. Her research interest is focused on structural lipids of actinobacteria as well as taxonomy and identification of novel actinobacterial species. She has used MALDI-TOF mass spectrometry for bacteria identification and a number of complementary methods for microbiological, biochemical and instrumental analysis. Her major achievement involved establishing a novel bacterial polar lipids class containing ether-linked alkyl chains and determination of the complete structures of four glycolipids of Propionibacterium propionicum which revealed a unique chemical structure, first discovered among the Actinobacteria class members. She has supervised 13 master’s theses and 4 bachelor’s (engineer’s) theses, and is currently supervising a PhD student.

Research interests:

Microbiology, glycolipid structure and biological activity, actinobacteria, lipid analysis, MALDI-TOF MS.

Major publications:

Saeed A., Paściak M., Górska S., et al. (2018). Scientific Reports, 8, 11564.

Paściak M., Górska S., Jawiarczyk N. et al. (2017). Microb Biotechnol, 10, 456-468.

Paściak M., Dacko W., Sikora J., et al. (2015). J Clin Microbiol, 53, 2611-2621.

Paściak M., Holst O., Lindner B. et al. (2003). J Biol Chem, 278, 3948-3956.

Gu Q., Paściak M., Luo H. et al. (2007). Int J Syst Evol Microbiol, 57, 809-814.

 ryszard.miedzybrodzki@hirszfeld.pl

@ www.iitd.pan.wroc.pl/en

Ryszard Międzybrodzki has been working at the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, in Wroclaw, Poland since 1996. He is a researcher, physician (MD), and a director of the Medical Center at the Hirszfeld Institute. He has conducted both preclinical studies on bacteriophage application in the treatment of bacterial infections at the Bacteriophage Laboratory as well as experimental phage therapy in humans at the Phage Therapy Unit (both headed by Prof. Andrzej Gorski) – the first center dedicated to phage therapy in the EU, where over 700 patients have been treated to date. Since 2013 he has been also working at the Department of Clinical Immunology of the Medical University of Warsaw. He has organized and conducted postgraduate training of Polish and foreign physicians, and courses in phage therapy for students. Moreover, in 2003-2012, he conducted research on isolation, culture and clinical application of human olfactory ensheathing cells and he was a member of a scientific team honored for “Functional regeneration of the spinal cord in a patient with full spinal injury following intraspinal transplantation of autologic olfactory ensheathing cells” with an award from the Polish Prime Minister in 2015. He was the supervisor for two Fulbright Foundation grantees who conducted their studies in phage biology. He has published over 80 papers and 6 book chapters, most of them related to the therapeutic phage application and phage biology, and has co-edited two books related to phage therapy.

Research interests:

1. The possibilities for the use of phages in the treatment of bacterial infections in humans (bioavailability and safety of phage application).
2. New directions of clinical use of bacteriophages (anti-inflammatory and immunomodulating phage effects).

Major publications:

Międzybrodzki R., Borysowski J., Weber-Dąbrowska B., Fortuna W., Letkiewicz S., Szufnarowski K., Pawełczyk Z., Rogóż P., Kłak M., Wojtasik E., Górski A., (2012). “Clinical aspects of phage therapy”, Adv Virus Res. 83:73-121.

Górski A., Międzybrodzki R., Borysowski J., Dąbrowska K., Wierzbicki P., Ohams M., Korczak-Kowalska G., Olszowska-Zaremba N., Łusiak-Szelachowska M., Kłak M., Jończyk E., Kaniuga E., Gołaś A., Purchla S., Weber-Dąbrowska B., Letkiewicz S., Fortuna W., Szufnarowski K., Pawełczyk Z., Rogoż P., Kłosowska D., (2012). “Phage as a modulator of immune responses: practical implications for phage therapy”, Adv Virus Res. 83:41-71.

Międzybrodzki R., Kłak M., Jończyk-Matysiak E., Bubak B., Wójcik A., Kaszowska M., Weber-Dąbrowska B., Łobocka M., Górski A., (2017). “Means to facilitate the overcoming of gastric juice barrier by a therapeutic staphylococcal bacteriophage A5/80”, Front Microbiol. 8:467.

Międzybrodzki R., Borysowski J., Kłak M., Jończyk-Matysiak M., Obmińska-Mrukowicz B., Suszko-Pawłowska A., Bubak B., Weber-Dąbrowska B., Górski A., (2017). “In vivo studies on the influence of bacteriophage preparations on the autoimmune inflammatory process”, Biomed Res Int. 2017:3612015.

Górski A. Międzybrodzki R., Łobocka M., Głowacka-Rutkowska A., Bednarek A., Borysowski J., Jończyk-Matysiak E., Łusiak-Szelachowska M., Weber-Dąbrowska B., Bagińska N., Letkiewicz S., Dąbrowska K., Scheres J., (2018). “Phage Therapy: What Have We Learned?”, Viruses. 10(6).pii:E288.

Przybylski M., Dzieciątkowski T., Borysowski J., Międzybrodzki R., Górski A., (2019). “Inhibitory effects of bacteriophage preparations on adenoviral replication”, Intervirology. 62(1):37-44.

Górski A., Międzybrodzki R., Jończyk-Matysiak E., Żaczek M., Borysowski J., (2019). “Phage-specific diverse effects of bacterial viruses on the immune system”, Future Microbiol.14:1171-1174.

Międzybrodzki R., Hoyle N., Zhvaniya F., Łusiak-Szelachowska M., Weber-Dąbrowska B., Łobocka M., Borysowski J., Alavidze Z., Kutter E., Górski A., Gogokhia L., (2018). “Current updates from the long-standing phage research centers in Georgia, Poland, and Russia” In: Harper D, Abedon S, Burrowes B, McConville M (Eds.), Bacteriophages (s. 1-31). Cham: Springer (ISBN: 978-3-319-40598-8).

Rogóż P., Amanatullah D.F., Międzybrodzki R., Manasherob R., Tikunova N.V., Weber-Dąbrowska B., Fortuna W., Letkiewicz S., Górski A., (2019). “Phage Therapy in Orthopaedic Implant-Associated Infections” In:  Górski A., Międzybrodzki R., Borysowski J. (Eds.), Phage Therapy: A Practical Approach (s. 189-211). Cham: Springer (ISBN: 978-3-030-26735-3).

Rostkowska O.M., Międzybrodzki R., Miszewska-Szyszkowska D., Górski A., Durlik M., (2020). “Treatment of recurrent urinary tract infections in a 60-year-old kidney transplant recipient. The use of phage therapy”, Transpl Infect Dis. 2020;e13391.

sabina.gorska@hirszfeld.pl

@ https://www.researchgate.net/profile/Sabina_Gorska

Sabina Górska leads the Microbiome Immunobiology Laboratory at the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (IIET PAS). She studied biotechnology at the Technical University in Wrocław, then earned her PhD in medical microbiology at IIET PAS. In 2012 she received a scholarship from the Ministry of Science and Higher Education for outstanding young scientists. Her research interests focus on analyzing the chemical structure of probiotic bacterial antigens involved in interactions with the host immune system and their effect on the host’s health, especially in the context of human diseases such as allergies, IBD, autoimmune and neurodegenerative diseases. She has spent research stays at the Swedish University of Agricultural Sciences, Uppsala, Sweden; Stanford University, United States; and the Laboratory of Gnotobiology, Novy Hradek, Czech Republic. She has obtained grants from the Polish Ministry of Science and Higher Education, Poland’s National Science Centre, and EU grants. The main research techniques used in her research are: instrumental analysis techniques (e.g. NMR; chromatographic methods; mass spectrometry), flow cytometry, fluorescence determination of intracellular Ca2 + concentration, RT-PCR, EMSA, reporter analysis (DLR).

Research interests:

Microbiome, immunobiology, bacterial surface antigens, probiotics, allergy.

Major publications:

Pacyga et al. (2020). Cells doi: 10.3390/cells9051146.

Piekarz I. et al. (2020). Biosen Biolectron. https://doi.org/10.1016/j.bios.2019.111784.

Pyclik M. et al. (2020). Int J Biol Macromol. doi: 10.1016/j.ijbiomac.2019.12.227.

Górska S. et al. (2017). Microb Biotechnol. doi: 10.1111/1751-7915.12606.

Górska S. et al. (2016). Sci. Rep. doi: 10.1038/srep37613.

 slawomir.koziel@hirszfeld.pl

Slawomir Koziel is a professor; he has headed the Department of Anthropology at the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (IIET PAS) since 2017. He earned his PhD at the University of Wroclaw in 1998, followed by his DSc (habilitation) in 2007. In 2016 he received the title of professor by nomination of the President of Poland. He has authored/co-authored more than 180 original publications, in such journals as Lancet, Nature, and Sports Medicine. He has promoted five PhD students and supervised 10 master’s theses. He has been the principal investigator on 3 national projects and participated in 7 others, plus 2 international, supported by the British Council and EU. He took part in 18 short-term scholarships, including 6 times at Oxford University (twice supported by the Royal Society). He is an international fellow of UBVO at Oxford University (https://www.oxfordobesity.org/research-network). He is a chairperson of Auxological Society (Germany) and editor-in-chief of the journal Anthropological Review. He is also a member of 3 other international scientific organisations.

Research interests:

Human biology, the growth and development of children; epidemiology of obesity; evolutionary ecology; biostatistics.

Major publications:

Malina R.M., Cumming S.P., Rogol A.D., Coelho-e-Silva M.J., Figueiredo A.J., Konarski J.M., Koziel S.M. (2019). “Bio-banding in youth sports: background, concept, and application”, Sports Medicine, 49(11): 1671-1685.

Koziel S., Ignasiak Z., Żądzińska E. (2019). “Exposure to parental smoking during pregnancy and handgrip strength in 7-10-year old children”, Early Human Development, 134: 7-11.

Koziel S., Malina R.M. (2018). “Modified maturity offset prediction equations: validation in independent longitudinal samples of boys and girls”, Sports Medicine, 48:221-236.

NCD Risk Collaboration (NCD-RisC). (2017). “Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurements studies in 128,9 million children, adolescents, and adults”, The Lancet, 390(10113): 2627-2642.

Nowak-Szczepanska N., Koziel S. (2016). “Sexual dimorphism in growth in the relative length of the forearm and relative knee height during adolescence”, American Journal of Physical Anthropology, 161, (2): 276-282.

 tomasz.niedziela@hirszfeld.pl

Tomasz Niedziela is an associate professor at the Hirszfeld Institute, Polish Academy of Sciences, Wrocław, and a researcher at the Laboratory of Microbial Immunochemistry and Vaccines. For over 20 years he has been deciphering complex bacterial carbohydrate structures, analyzing and compiling the structural features with complementary immunological properties into a multidisciplinary description of the investigated bacterial antigens. He has been applying the structural glycomics to facilitate the creation of a new generation of antibacterial vaccines and to improve the existing ones. For 3 years he was a postdoctoral fellow at the Department of Chemistry, SLU, Uppsala, Sweden, investigating a new approach to the analysis of complete bacterial carbohydrate antigens and acquiring skills in applications of NMR spectroscopy, including HR-MAS NMR and STD-NMR, as well as mass spectrometry for immunochemical analysis. His principal research focus is on the neoglycocojugate components of pertussis vaccine. He is also the head of the NMR Facility at the Hirszfeld Institute.

Research interests:

Immunochemistry, neoglycoconjugate vaccines, Bordetella pertussis, NMR applications in structural glycomics.

Major publications

Niedziela T., Letowska I., Lukasiewicz J., Kaszowska M., Czarnecka A., Kenne L., Lugowski C. (2005). “Epitope of the vaccine-type Bordetella pertussis strain 186 lipooligosaccharide and antiendotoxin activity of antibodies directed against the terminal pentasaccharide-tetanus toxoid conjugate”, Infect Immun. 73; 7381-7389. doi:10.1128/IAI.73.11.7381-7389.2005.

Patents granted:

US 9,878,051 B2 (2018-01-30) & EP 14744634.8 (2018-09-12) Koj S., Niedziela T., Ługowski C. “Bordetella pertussis los-derived oligosaccharide with pertussis toxin glycoconjugate and its application in the prophylaxis and treatment of infections caused by Bordetella pertussis”.

 krzysztof.pawlik@hirszfeld.pl

@ https://www.researchgate.net/profile/Krzysztof-Pawlik

@ https://twitter.com/KubaPawlik9

Krzysztof Jakub Pawlik earned his PhD from the Hirszfeld Institute of Immunology and Experimental Therapy in 2002. In the years 2002-2005 he got postdoc fellowship at Prof. Jean-Luc Pernodet laboratory (University of Paris Sud IX) and stayed as a research fellow at Prof. Eriko Takano lab (Department of Microbiology at University of Tübingen). His research interests focuses on molecular basis of secondary metabolites synthesis. He is particularly interested in the synthesis of polyketides by Streptomyces bacteria. Since 2018 he cooperates with prof. K. Matczyszyn from Wrocław University of Science and Technology to develop an application of photodynamic therapy against pathogens of skin infections.

Research interests:

Antimicrobial photodynamic therapy (aPDT), Specialized metabolites, Secondary metabolite biosynthesis pathways, Synthetic Biology, Streptomyces,

Major publications:

Bednarz B., Millan-Oropeza A., Kotowska M., Swiat M., Quispe Haro J.J., Henry C., Pawlik K.J. Coelimycin synthesis activatory proteins are key regulators of specialized metabolism and precursor flux in Streptomyces coelicolor A3(2). Front. Microbiol., (2021) doi: 10.3389/fmicb.2021.616050.

Maldonado-Carmona N., Marchand G., Villandier N., Ouk T-S, Pereira M.M., Calvete M.J.F., Calliste C.A., Żak A., Piksa M., Pawlik K.J., Matczyszyn K., Leroy-Lhez S. Porphyrin-Loaded Lignin Nanoparticles Against Bacteria: A Photodynamic Antimicrobial Chemotherapy Application. Front. Microbiol., (2020) doi.org/10.3389/fmicb.2020.606185

Chen l., Piksa M., Yoshida K., Persheyev S., Pawlik K.J., Matczyszyn K. Samuel IDW. Flexible organic light-emitting diodes for antimicrobial photodynamic therapy. npj Flexible Electronics (2019) 3:18; doi.org/10.1038/s41528-019-0058-0

Bednarz B., Kotowska M., Pawlik K. Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2). Appl Microbiol Biot 103, 6423–6434(2019) doi.org/10.1007/s00253-019-09975-w.

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