Ryszard Ostaszewski graduated from the Warsaw Technical University in 1985. Since then he has been employed at the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS), where he earned his academic degrees (PhD in 1989 under the supervision of Prof. Janusz Jurczak, DSc/habilitation in 1999, and professorship in 2009). He spent a postdoctoral stay at the University of Twente, the Netherlands, working with Profe. David N. Reinhoud (1989–1990) and at the University of Zurich, Switzerland, working with Prof. Hans-J. Hansen (1994-1995). Since 2009 he has held the position of full professor at Institute of Organic Chemistry PAS. His scientific interests comprise chemistry and stereochemistry of multicomponent reactions, biocatalytic syntheses of enantiomerically pure peptidemimetics, enzyme immobilization and domino/cascade chemoenzymatic processes. He is the author or coauthor of over 110 publications, including one book chapter. He has been the organizer of three international conferences, devoted to applications of enzymes in organic chemistry. He has supervised nine PhD theses; a further four are pending.
Biocatalysis, stereochemistry, medicinal chemistry, multicomponent reactions
Serrano-Luginbühl S., Ruiz-Mirazo K., Ostaszewski R., Gallou F., Walde P. (2018). “Soft and dispersed interface- rich aqueous systems that promote and guide chemical reactions”, Nature Review Chemistry, 2, 306 – 327.
Paprocki D., Madej A., Koszelewski D., Brodzka A., Ostaszewski R. (2018). “Multicomponent reactions accelerated by aqueous micelles”, Frontiers in Chemistry , 6, 502.
Koszelewski D., Brodzka A., Żądło A., Paprocki D., Trzepizur D., Zysk M., Ostaszewski R. (2016). “Dynamic Kinetic Resolution of 3-aryl-4-Pentenoic Acids” , ACS Catal., 6, 3287−3292.
Ufnal M., Żądlo A., Ostaszewski R. (2015). “TMAO, a small molecule of great expectations”, Nutrition, 31, 1317-1323.
Agnieszka Szumna is a professor and a group leader at the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS), Warsaw, Poland. She earned her MSc degree from Warsaw University (in crystallography, 1996) and her PhD in supramolecular chemistry (2001) working on neutral anion receptors under the supervision of Prof. J. Jurczak. She was a postdoctoral fellow with Prof. Jerry L. Atwood at University of Missouri, Columbia, USA (2001-2003). In 2004 she was appointed an assistant professor, in 2012 an associate professor and in 2019 a full professor at the Institute of Organic Chemistry PAS. She received awards for an outstanding DSc (habilitation) thesis from the Polish Prime Minister and Division III of Polish Academy of Sciences. In 2017 she received the Curie-Klemm lectureship award by a joint decision of the Polish Chemical Society (PTChem) and German Chemical Society (GDCh).
Artificial peptide based porous structures, chiral recognition, reactivity and dynamics in confined spaces, mechanochemistry, organic synthesis.
Szumna A. (2020), Chem. Eur. J., 26, 1558-1566.
Szumna A. (2019). Chem. Eur. J., 25, 3091-3097.
Szumna A. (2019). Chem. Sci., 10, 4412-4421.
Szumna A. (2014). Angew. Chem. Int. Ed., 53, 13760-13764.
Bartłomiej Furman earned his PhD in 1998 working with Marek Chmielewski at the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS). After one and a half years of post-doctoral research with Horst Kunz at the University of Mainz (as a Humboldt Fellow), he returned to Institute of Organic Chemistry PAS where continued his scientific development. In 2006, he embarked on his independent career at the Institute, where he is currently a professor of chemistry (since 2014). He has been awarded several prizes, including the Foundation for Polish Science Award for Young Scientists and the Polish Prime Minister’s Award for PhD Thesis. The findings of his group have been published in almost 100 original articles and reviews, focusing on methodology development in the area of synthetic chemistry, new materials and catalysis. Current research topics: (a) chemoselective activation of amide carbonyls towards nucleophilic reagents, (b) mechanochemistry in the synthesis of organometallic compounds and low-valent salts, (c) new strategies for the synthesis of macrocyclic compounds, (d) studies on the rearrangement of vinyl ethers and alkoxydienes, (e) stereoselective method of β-lactams synthesis.
Activation of small inert molecules, mechanochemistry, asymmetric synthesis, target oriented synthesis, macrocyclic compounds synthesis.
Popik O., Grzeszczyk B. , Staszewska-Krajewska O., Furman B., Chmielewski M. (2020). “Synthesis of β-lactams via diastereoselective, intramolecular Kinugasa reactions”, Org. Biomol. Chem., 18, 2852-2860, doi: 10.1039/D0OB00228C.
Czerwiński P. J., Furman B. (2019). “Overcoming inaccessibility of fluorinated imines – synthesis of functionalized amines from readily available fluoroacetamides”, Chem. Commun., 55, 9436-9439, doi: 10.1039/C9CC04111G.
Domżalska-Pieczykolan A. , Furman B. (2020). “Beyond the Tebbe Olefination: Direct Transformation of Esters into Ketones or Alkenes”, Synlett, 31, 730-736, doi: 10.1055/s-0039-1691594.
Ulikowski A. , Furman B. (2016). “Schwartz’s Reagent-Mediated Regiospecific Synthesis of 2,3-Disubstituted Indoles from Isatins” , Org. Lett., 18, 149-153, doi: 10.1021/acs.orglett.5b03449.
Dorota Gryko earned her PhD from the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh, PAS) in 1997, under the supervision of Prof. J. Jurczak. After a post-doctoral stay with Prof. J. Lindsey in North Carolina State University (1998–2000), she started an independent career in Poland. In 2009 and 2018, she received the prestigious TEAM grants from the Foundation for Polish Science. For her scientific achievements, she has been commended by the Polish Minister of Science and Higher Education. Her current research interests are focused on light-induced processes with particular attention being paid to porphyrinoid catalysis as well as on vitamin B12 chemistry.
Sustainable catalysis, photochemistry, photocatalysis, cobalt-catalysis, vitamin B12 chemistry.
Ociepa M., Wierzba A. J., Turkowska J., Gryko D., (2020). “Polarity-Reversal Strategy for the Functionalization of Electrophilic Strained Molecules via Light-Driven Cobalt Catalysis”, J. Am. Chem. Soc., 142, 5355–5361. Spotlight in J. Am. Chem. Soc., 142, 5911–5912.
Braselmann E., Wierzba A. J., Polaski J. T., Chromiński M., Holmes Z. E., Hung S., Batan D., Wheeler J. R., Parker R., Jimenez R. , Gryko D., Batey R. T., Palmer A. E. (2018). “A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells”, Nat. Chem. Bio., 14, 964–971.
Równicki M., Wojciechowska M., Wierzba A. J., Czarnecki J., Bartosik D., Gryko D., Trylska J. (2017). “Vitamin B12 as a carrier of peptide nucleic acid (PNA) into bacterial cells” Scientific Reports, 7, 7644.
Dominik Koszelewski is an assistant professor (since 2007) at the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS). He earned his PhD from the Institute of Organic Chemistry PAS, next spent a 2.5-year postdoctoral fellowship at the University of Graz in Austria, working in the group of Kurt Faber and Wolfgang Kroutil. He earned his DSc (habilitation) in chemistry in 2020.
Synthesis of non-racemic pharmaceutically relevant compounds, biocatalysis.
Koszelewski D., et al., (2008). “Formal asymmetric biocatalytic reductive amination”, Angewandte Chemie, 120 (48), 9477-9480;
Koszelewski D., Ostaszewski R., (2019). “Biocatalytic Promiscuity of Lipases in Carbon‐Phosphorus Bond Formation”, ChemCatChem , 11 (10), 2554-2558;
Koszelewski D., et al, (2016). “Dynamic kinetic resolution of 3-aryl-4-pentenoic acids”, ACS Catalysis, 6 (5), 3287-3292.
Daniel T. Gryko earned his PhD from the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS) in 1997, under the supervision of Prof. J. Jurczak. After a post-doctoral stay with Prof. J. Lindsey at North Carolina State University (1998–2000), he started his independent career in Poland. He became a full professor in 2008. The same year he received the Society of Porphyrins and Phthalocyanines Young Investigator Award and in 2017 Foundation for Polish Science Award. In 2009 and 2017, he received the prestigious TEAM grants from the Foundation for Polish Science. His current research interests are focused on the synthesis of various functional dyes as well as on two-photon absorption, solvatofluorochromism, excited-state intramolecular proton transfer and fluorescence probes. Since 2019 he has been the director of the Institute of Organic Chemistry, PAS.
Functional dyes, porphyrins, fluorescence, nanographenes.
Mishra S., Krzeszewski M., Pignedoli C. A., Ruffieux P., Fasel R., Gryko D. T. (2018). “On-surface synthesis of a nitrogen-embedded buckybowl with inverse Stone–Thrower–Wales topology”, Nature Commun., 1714.
Krzeszewski M., Espinoza E. M., Červinka C., Derr J. B. , Clark J. A., Borchardt D., Beran G. J. O., Gryko D. T., Vullev V. I. (2018). “Dipole Effects on Charge Transfer are Enormous”, Angew. Chem. Int. Ed., 57, 12365-12369.
Koszarna B., Gryko D. T. (2006). “Efficient synthesis of meso-substituted corroles in a H2O-MeOH mixture”, J. Org. Chem., 71, 3707-3717.
Grzybowski M., Glodkowska-Mrowka E. , Stoklosa T., Gryko D.T. (2013). “Bright, color-tunable fluorescent dyes based on π–expanded diketopyrrolopyrroles”, Org. Lett., 14, 2670-2673.
Grzybowski M., Skonieczny K., Butenschön H., Gryko D. T. (2013). “Oxidative aromatic coupling versus Scholl reaction”, Angew. Chem. Int. Ed., 52, 9900-9930.
Jacek Mlynarski is a professor and group leader at the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS). He earned his PhD (2000) from the Institute of Organic Chemistry PAS. In 2001 he obtained a research fellowship from the Alexander von Humboldt Foundation and worked with Prof. Alois Fürstner at the Max Planck Institut für Kohlenforschung. Upon returning to Poland in 2002 he obtained an academic position in Warsaw and was also professor at the Faculty of Chemistry, Jagiellonian University in Krakow (2008-2018).
Organic synthesis, asymmetric catalysis, zinc-complexes, natural products.
Mlynarski J., (2020). Adv. Synth. Catal., 362, 1532.
Mlynarski J., (2020). Chem., 6, 280.
Mlynarski J., (2020). Adv. Synth. Catal., 362, 667.
@ www.icho.edu.pl/grela/ @ www.karolgrela.eu
Karol Grela (H-index 44) earned his MSc from the Warsaw University of Technology and his PhD from the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS). As an Alexader von Humboldt Scholar, he spent one year at the Max-Planck-Institut für Kohlenforschung in the laboratories of Prof. Alois Fürstner. Next, he returned to Warsaw, and completed his DSc (habilitation) degree in 2003. In 2008 he was promoted to full professor. He has cooperated with a number of companies, including Boehringer-Ingelheim Inc., Nalco Inc., Evonik AG, Umicore AG, Polpharma SA, and Apeiron Synthesis SA. He has received a number of prizes, including the Alexander von Humboldt Fellowship (1999), Maria Curie and Wilhelm Klemm Lectureship of the German Chemical Society (2007), Polish Prime Minister’s Prizes (1999, 2004 & 2010), the Prize of the Foundation for Polish Science (2014) and French Chemical Society Prize (2016). Since 2018 he has been a Fellow of Chemistry Europe. He is the member of the editorial boards of Chemistry – A European Journal, European Journal of Organic Chemistry, Chemistry Select and associate editor of Beilstein Journal of Organic Chemistry. He has co-authored of more than 190 scientific papers and numerous patents.
Organic chemistry; catalysis; natural products; organometallic compounds; synthesis.
Sytniczuk A., Dąbrowski M. , Banach Ł., Urban M., Czarnocka-Śniadała S., Milewski M., Kajetanowicz A., Grela K. (2018). “At Long Last: Olefin Metathesis Macrocyclization at High Concentration” , J. Am. Chem. Soc., 140, 8895-8901, cited 20, IF=14.612.
Clavier H., Grela K., Kirschning A., Mauduit M., Nolan S. P. (2007). “Sustainable Concepts in Olefin Metathesis”, Angew. Chem. Int. Ed., 46, 6786-6801 (a review), cited 300, IF=12.959.
Samojłowicz C., Bieniek M., Grela K. (2009). “Ruthenium-Based Olefin Metathesis Catalysts Bearing N-Heterocyclic Carbene Ligands”, Chem. Rev., 109, 3708-3742 (a review), cited 779, IF=52.758.
Michrowska A., Bujok R., Harutyunyan S., Sashuk V., Dolgonos G., Grela K. (2004). “Nitro-Substituted Hoveyda-Grubbs Ruthenium Carbenes: Enhancement of Catalysts Activity through Electronic Activation”, J. Am. Chem. Soc., 126, 9318-9325, cited 382, IF=14.612.
Grela K., Harutyunyan S., Michrowska A. (2002). “A New Highly Efficient Ruthenium Catalyst for Metathesis Reaction”, Angew. Chem. Int. Ed., 41, 4038-4040, cited 358, IF=12.959.
Maciej Giedyk graduated with a ME in chemistry from the Warsaw University of Technology, Poland, in 2012. He earned his PhD at the Institute of Organic Chemistry, Polish Academy of Sciences (IOch PAS) under the supervision of Prof. Dorota Gryko in 2016, working on the synthesis and catalytic properties of vitamin B12 derivatives. In early 2018, he took up a postdoctoral position in the group of Prof. Burkhard König at the University of Regensburg. In 2019 he was appointed assistant professor at the Institute of Organic Chemistry PAS.
Light-induced processes, the chemistry of organic halides, cobalt-catalysis and microheterogenous solutions.
Giedyk M. et al. (2003). Nat. Catal., 3, 40.
Petzold D., Giedyk M. et al. (2020). Eur. J. Org. Chem., 15, 1193.
Giedyk M. et al. (2019). Chem. Commun., 55, 763.
Giedyk M.et al. (2017). Org. Lett., 19, 2670.
Giedyk M.et al. (2016). Chem. Commun., 52, 1389.
Giedyk M. et al. (2015). Chem. Soc. Rev., 44, 3391.
Giedyk M. et al. (2014). Chem. Commun., 50, 4674.
Zbigniew Pakulski earned his PhD from the Institute of Organic Chemistry, Polish Academy of Sciences (IOCh PAS). Next he spent a 2-year postdoctoral fellowship at Industrial Research Limited (Lower Hutt, New Zealand) in Dr. Richard Furneaux’s laboratory. Afterwards, he returned to Warsaw. Currently, he is an associate professor at Institute of Organic Chemistry, PAS. He has strong experience in carbohydrate synthesis including glycosylation, elongation of sugar chains, synthesis of unusual natural sugars (e.g. heptoses and 6-deoxyheptoses), and the application of organometallic chemistry in monosaccharide synthesis. Recently, his research has focused on the chemistry of triterpenes isolated from outer birch bark (betulin, betulinic acid) and saponins prepared from them. Derivatives of betulin show high cytotoxic activity and are interesting targets in the synthesis. He is now concentrated on the deep modification of triterpene core structure towards new anticancer derivatives. It includes incorporation of sulfur, selenium, and phosphorus as heteroatoms to the triterpene structure, and rearrangement of lupane core. Such transformations increase bioactivity and bioavailability of the studied compounds. They can also be used as starting materials in the synthesis of analogues of natural products.
Stereoselective synthesis, glycosylation, chemistry of triterpenes, natural compounds, biological activity.
Pakulski Z. (2017). “Sugar migration induced by the Wagner-Meerwein rearrangement of 28-O-glycosyl-betulin derivatives”, Tetrahedron, 73, 1740.
Pakulski Z. (2016). “Influence of intramolecular hydrogen bonds on regioselectivity of glycosylation. Synthesis of lupane-type saponins bearing the OSW-1 saponin disaccharide unit and its isomers”, Carbohydr. Res., 423, 49.
Pakulski Z. (2016). “Synthesis and cytotoxicity of 28a-homothiolupanes and 28a-homothiolupane saponins”, Eur. J. Org. Chem., 373.
Pakulski Z. (2016). “Synthesis of 28a-homoselenolupanes and 28a-homoselenolupane saponins”, Org. Biomol. Chem., 14, 10238.
Przemysław Gaweł is an assistant professor at the Institute of Organic Chemistry Polish Academy of Sciences. After studying Chemistry and Biotechnology at the University of Warsaw he completed his Ph. D. in the group of Prof. François Diederich at ETH Zurich, Switzerland where he studied cumulene-based functional materials. In 2015, he moved to Oxford as a Swiss National Science Foundation Postdoc. Mobility Fellow to study new carbon allotropes in the group of Prof. Harry L. Anderson. In 2020, he received a Polish Returns grant from NAWA to start his research group studying novel organic electronic materials.
Physical organic synthesis, organic electronics, materials science, supramolecular chemistry
Science 2019, 365, 1299
Nat. Chem. 2018, 10, 853
Angew. Chem. Int. Ed. 2020, https://doi.org/10.1002/anie.202013623
He studied at the Adam Mickiewicz University in Poznań, where in 2010 he completed Bachelor in Chemistry (under supervision of Prof. Bogdan Marciniec) and subsequently, in 2014, Master in Organic Stereochemistry developing a thesis under supervision of Prof Jacek Gawroński. Next, in 2012, he moved to the Institute of Nanotechnology, Karlsruhe Institute of Technology (Germany) to work as a young researcher in the group of Prof. Marcel Mayor. Meantime, Marcin was enrolled at the University of Basel as a PhD student. Late, in 2016, He defended a PhD dissertation entitled “Tailor-made tetraphenylmethanes : from surface decoartion to 3D organic polymers” (magna cum laude). In 2017 he returned to Poland to work at Selvita company (custom chemistry department) as Synthesis Specialist III. Upon short adventure in industry he returned to academia (Institute of Organic Chemistry, Polish Academy of Science) to work with Prof. Janusz Jurczak (2017-2018) and Prof. Karol Grela (2019). In two 2019 Marcin won Sonata 14, while in 2020 Lider XI grant competitions. Currently, He is employed as assistant professor and appointed a head of the team XB at the IOC, PAS in Warsaw.
organic synthesis, curved aromatic nanostructures, TADF OLED emitters
Chemistry–A European Journal 2016 22 (37), 13218-13235
Angewandte Chemie International Edition 2017, 56 (28), 8290-8294
Chemical Communication 2019 55, 3351-3354
Jaroslaw Granda is an assistant professor at the Institute of Organic Chemistry, Polish Academy of Sciences. He received his Ph.D. (2015) from the Institute of Organic Chemistry under the supervision of Prof. J. Jurczak. In 2015, he obtained research fellowship from Ministry of Higher Education of Poland to work on chemical robotics with Prof. Lee Cronin at the University of Glasgow. He returned to Poland in 2021, after receiving a Polish Returns grant from NAWA, to start his research group studying new machine learning-driven approaches to asymmetric catalysis.
asymmetric catalysis, computer aided reaction discovery, navigation of chemical space.
Nature, 2018, 559, 377.
Science, 2019, 363, eaav2211.
Nat. Chem. 2021, 13, 63.
Sebastian Stecko is an associated professor and group leader at the Institute of Organic Chemistry Polish Academy of Sciences. He received his Ph.D. (2008) from the Institute of Organic Chemistry PAS. In 2010 he obtained research fellowship from the Alexander von Humboldt Foundation and worked with prof. Siegfried Blechert at the Berlin Technical University. Upon returning to Poland in 2011 he have started his independent scientific career. In 2016 he received his D.Sc. (habilitation) from the Institute of Organic Chemistry PAS.
organic synthesis, asymmetric catalysis, stereocontrolled synthesis, transition-metal catalysis, photoredox catalysis, electrosynthesis, bioactive compounds
Org. Biomol. Chem, 2021, 19, 8578
Adv. Synth. Catal. 2020, 362, 3213
Org. Biomol. Chem., 2018, 16, 3921
Org. Chem., 2017, 82, 5636