Supervisors from International Institute of Molecular Mechanisms and Machines

a.chacinska@imol.institute

Prof. Agnieszka Chacinska is a director of the International Institute of Molecular Mechanisms and Machines PAS (from 2020) and head of ReMedy, the International Research Agenda Program (from 2017). She received a PhD from the Institute of Biochemistry and Biophysics, PAS with Prof. Magdalena Boguta and post-doctoral training with Prof. Nikolaus Pfanner, followed by a junior group leader position at the University of Freiburg, Germany. Subsequently, she was a Head of the Laboratory of Mitochondrial Biogenesis at the International Institute of Molecular and Cell Biology in Warsaw (2009-2017), where she obtained a full professorship. In 2017, she undertook a position at the University of Warsaw, Centre of New Technologies. The Chacinska laboratory of Mitochondrial Biogenesis is currently moving to IMol PAS.

Prof. Agnieszka Chacińska is corresponding member of PAS, member of EMBO and Academia Europea.

Research interests:

Molecular and cell biology, biogenesis, mitochondria, transport and degradation of proteins, cellular protein homeostasis,

Major publications:

Mohanraj, K., Wasilewski, M., Benincá, C., Cysewski, D., Poznanski, J., Sakowska, P., Bugajska Z., Deckers M., Dennerlein S., Fernandez-Vizarra E., Rehling P., Dadlez M., Zeviani M., Chacinska A. (2019). Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7. EMBO Molecular Medicine, 11(5). DOI: 10.15252/emmm.201809561

Topf, U., Suppanz, I., Samluk, L., Wrobel, L., Böser, A., Sakowska, P., Knapp, B., Pietrzyk, M. K., Chacinska*, A., & Warscheid*, B. (2018). Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species. Nature Communications, 9(1), 324, DOI:10.1038/s41467-017-02694-8. (*co-corresponding authors)

Gold, V.A.M., Chroscicki, P., Bragoszewski, P., Chacinska, A. (2017). Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography. EMBO Reports, DOI 10.15252/embr.201744261.

Wrobel, L., Topf, U., Bragoszewski, P., Wiese, S., Sztolsztener, M.E., Oeljeklaus, S., Varabyova, A., Lirski, M., Chroscicki, P., Mroczek, S., Januszewicz, E., Dziembowski, A., Koblowska, M., Warscheid*, B., Chacinska*, A. (2015). Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature, 524, 485-488. (*co-corresponding authors)

Bragoszewski, P., Wasilewski, M., Sakowska, P., Gornicka, A., Böttinger, L., Qiu, J., Wiedemann, N., Chacinska, A. (2015). Retro-translocation of mitochondrial intermembrane space proteins. Proc Natl Acad Sci U S A. 112, 7713-7718.

m.konarska@imol.institute

Prof. Magda Konarska is a deputy director for science at the International Institute of Molecular Mechanisms and Machines PAS (from 2021) and a deputy director of the International Research Agenda Program – ReMedy (from 2017). She received a PhD from the Institute of Biochemistry and Biophysics, PAS (with prof. Witold Filipowicz) and post-doctoral training with prof. Phillip A. Sharp, Cancer Research Center, MIT, Cambridge, MA, USA. Subsequently, for over 25 years, she was a Head of the Molecular Biology and Biochemistry Laboratory at the Rockefeller University, New York, NY, USA. In 2015, she resigned from the Evelyn Gruss Lipper Full Professor position at the Rockefeller University and moved to Center for New Technologies, University of Warsaw, where she established a Laboratory of RNA Biology. From 2021, she will continue to head the Laboratory of RNA Biology at IMol, PAS. Prof. Konarska is a corresponding member of PAS, a member of EMBO and Academia Europea.

Research interests:

RNA Biology, pre-mRNA splicing, spliceosome, snRNA core of the catalytic center

Major publications:

Konarska, M.M., Vilardell, J. and Query C.C. Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Molecular Cell 21, 543-553 (2006).

Liu, L., Query, C.C. and Konarska, M.M. Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing. Nature Struct. Mol. Biol. 14, 519-526 (2007).

Smith, D.J., Query, C.C. and Konarska, M.M. Trans-Splicing to Spliceosomal U2 snRNA Suggests Disruption of Branch Site-U2 Pairing during Pre-mRNA Splicing. Molecular Cell  26, 883-890 (2007).

Smith, D.J., Konarska, M.M. and Query, C.C.  Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast.  Molecular Cell  34, 333-343 (2009).

Eysmont K, Matylla-Kulińska K, Jaskulska A, Magnus M, and Konarska MM. Rearrangements within the U6 snRNA core during the transition between the two catalytic steps of splicing. Molecular Cell  75(3):538-548 (2019).


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