Anna Wójcik-Gładysz’s team studies the neuromodulatory effects of neuropeptides and peripheral hormones involved in appetite regulation on animal growth and reproduction. In recent years, work has focused on the activity of the gastrointestinal hormones ghrelin and obestatin and their participation in the regulation of gene and protein expression of key hormones of the gonadotrophic and somatotrophic axis in the hypothalamic-pituitary system. Another objective of the team is the action of BDNF in depressive disorders associated with obesity, which simultaneously generate irregularities in the functioning of the gonadotrophic axis. Research is conducted on sheep, which is not a typical model for application research; however, the obtained results provide valuable and unique information that forms the basis for further research, leading to a better understanding of the processes underlying such disorders as anorexia and bulimia.
Neuroendocrinology, hormone regulation, animal physiology.
Przybył B.J., Szlis M., Wójcik-Gładysz A. (2020). “Brain-derived neurotrophic factor affects mRNA and miRNA expression of the appetite regulating centre in the sheep arcuate nucleus”, Annals of Animal Science, DOI: https://doi.org/10.2478/aoas-2020-0015.
Wójcik-Gładysz A. Szlis M., Przybył B.J., Polkowska J., (2019). “Obestatin may affect the GnRH/KNDy gene network in sheep hypothalamus”, Research in Veterinary Science, 123, 51-58; DOI: 10.1016/j.rvsc.2018.12.010.
Wójcik-Gładysz A. Wańkowska M., Gajewska A., Misztal T., Zielińska-Górska M., Szlis M., Polkowska J., (2016). “Effects of intracerebroventricular infusions of ghrelin on secretion of follicle-stimulating hormone in peripubertal female sheep”, Reproduction, Fertility and Development, 28 (12), pp. 2065-2074. DOI: 10.1071/RD16028.
Anna Antuszewicz (Antushevich H.) graduated with honors from the Grodno State Agrarian University in Belarus (BSc) and the Warsaw University of Life Sciences SGGW, Faculty of Animal Science in Poland (MSc, PhD). She obtained her DSc (habilitation) in 2017). Currently, she is a professor at the the Department of Genetic Engineering at the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences (Jabłonna, Poland). Her research interests concentrate on: 1) the role of adipose tissue and regulatory peptides in gastrointestinal tract functioning (intestinal epithelium maturation, digestive enzymes secretion, inflammation); 2) the role of adipose tissue in bacterial adhesion to enterocytes (in vitro experiments); 3) the role of fecal microbiota transplantation in gastrointestinal disease therapy. Also, she is involved in studies concerning the effect of endotoxin-induced inflammation on the hypothalamic-pituitary-gonadal axis in ewes.
Gastrointestinal tract physiology, inflammatory bowel diseases, regulatory peptides, bacterial adhesion, obesity, fecal microbiota transplantation.
Antushevich H. (2020). “Fecal microbiota transplantation in disease therapy”, Clinica Chimica Acta. 503: 90–98.
Antushevich H., Wójcik M. (2018). “Review: Apelin in disease”, Clinica Chimica Acta. 483: 241-248.
Antushevich H., Kapica M., Krawczyńska A., Herman A. P., Kato I., Kuwahara A., Zabielski R. (2016). “The role of apelin in the modulation of gastric and pancreatic enzymes activity in adult rats”, Journal of Physiology and Pharmacology. 67: 403-409.
Antushevich H., Bierła J., Pawlina B., Kapica M., Krawczyńska A., Herman A.P., Kato I., Kuwahara A., Zabielski R. (2015). “Apelin’s effects on young rat gastrointestinal tract maturation”, Peptides. 65: 1-5.
Antushevich H., Krawczyńska A., Kapica M., Herman A.P., Zabielski R. (2014). “Effect of apelin on mitosis, apoptosis and DNA repair enzyme OGG 1/2 expression in intestinal cell lines IEC-6 and Caco-2”, Folia Histochemica et Cytobiologica. 52: 51-59.
Małgorzata Białek holds a PhD in agricultural sciences, having graduated from the Faculty of Human Nutrition and Consumption Sciences of the Warsaw University of Life Sciences. Since 2016 she has been working at the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, firstly as a research assistant and then as an assistant professor. Her scientific interests are focused on conjugated fatty acids (CLA and CLnA isomers): methods of analysis, metabolism and mechanisms of actions, under both physiological and pathological conditions. She has also been working on assessing the effects of dietary supplementation of both laboratory and farm animals with bioactive compounds (fish oil, pomegranate seed oil, carnosic acid, seleno-compounds, lycopene) on the lipids profile, enzyme activity, antioxidant status and content of the elements in selected tissues.
Lipidomics, conjugated fatty acids – metabolism and mechanisms of actions under physiological and pathological conditions, peroxidation, chromatography, chemometrics.
Białek M., Białek A., Czauderna M. (2020). “Maternal and early postnatal diet supplemented with conjugated linoleic acid isomers affect lipid profile in hearts of offspring rats with mammary tumors”, Animals, 10 (3), 464.
Białek M., Białek A., Czauderna M. (2019). “Conjugated linoleic acid isomers affect profile of lipid compounds and intensity of their oxidation in heart of rats with chemically induced mammary tumors – preliminary study”, Nutrients, 11, 9, 2032.
Białek M., Białek A., Lepionka T., Paśko P., Galanty A., Tokarz A., Czauderna M. (2019). “Punica granatum (pomegranate) seed oil and Momordica charantia (bitter melon) extract affect the lipids profile and oxidative stability of femoral muscles of rats”, European Journal of Lipid Science and Technology, 121, 5, 1800420.
Białek M., Czauderna M., Białek A. (2018). “Partial replacement of rapeseed oil with fish oil and dietary antioxidants supplementation affects concentrations of biohydrogenation products and conjugated fatty acids in rumen and selected lamb tissues”, Animal Feed Science and Technology, 241, 63-74.