Supervisors from the Maj Institute of Pharmacology

 wierons@if-pan.krakow.pl

Joanna Wierońska has worked at the Maj Institute of Pharmacology, Polish Academy of Sciences in Kraków since 1997 – first at the Department of Pharmacology, since 1999 at the Department of Neurobiology.  She is currently a senior scientist and heads the Department of Neurobiology. The main field of her interest lies in the drug-drug interaction study and neurobiological mechanisms of the pathophysiology of central nervous system disorders. Her latest research has investigated the activity of the receptors involved in the regulation of glutamatergic pathways in the brain, including GABAB, muscarinic and metabotropic glutamate receptors. The activators of those receptors were studied in animal models of schizophrenia. Putative benefits and limits of those ligands given alone or in several different combinations of two ligands were studied, showing that the risk associated with the induction of adverse effects and the therapeutic potential may be better when the subeffective doses of two compounds are administered simultaneously. Her ongoing studies concern the role of nitric oxide dependent pathways in the efficacy of muscarinic and metabotropic glutamate receptor ligands.

 

Research interests:

Gutamate receptors, muscarinic receptors, schizophrenia, cognition.

 

Major publications:

Cieślik P., Domin H., Chocyk A., Gruca P., Litwa E., Płoska A., Radulska A., Pelikant-Małecka I., Brański P., Kalinowski L., Wierońska J.M. (2020). “Simultaneous activation of mGlu2and muscarinic receptors reverses MK-801-induced cognitive decline in rodents”,  Neuropharmacology,Sep 1;174:107866.

Cieślik P., Radulska A., Pelikant-Małecka I., Płoska A., Kalinowski L., Wierońska J.M. (2019). “Reversal of MK-801-Induced Disruptions in Social Interactions and Working Memory with Simultaneous Administration of LY487379 and VU152100 in Mice”, Int J Mol Sci. Jun 6;20(11):2781.

Wierońska J.M, Pilc A. (2019). “Depression and schizophrenia viewed from the perspective of amino acidergic neurotransmission: Antipodes of psychiatric disorders”, Pharmacol Ther., Jan;193:75-82.

Cieślik P., Woźniak M., Rook J.M., Tantawy M.N., Conn P.J., Acher F., Tokarski K., Kusek M., Pilc A., Wierońska J.M. (2018). “Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia- related changes in rodents”, Psychopharmacology (Berl). Oct;235(10):2897-2913.

Woźniak M., Gołembiowska K., Noworyta-Sokołowska K., Acher F., Cieślik P., Kusek M., Tokarski K., Pilc A., Wierońska J.M. (2017). “Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-2022”, Neuropharmacology. 2017 Mar 15;115:149-165.

 nalepa@if-pan.krakow.pl

@ http://if-pan.krakow.pl/en/departments/department-of-brain-biochemistry/

Irena Nalepa joined the Institute of Pharmacology, Polish Academy of Sciences in 1986. In 2007-2017 she served as its deputy director for general affairs. Since 2007 she has headed the Department of Brain Biochemistry. She earned her MSc in Biochemistry from the Jagiellonian University in Kraków and her PhD in Natural Sciences / Clinical Chemistry from the Medical University, Kraków, Poland. In 1994 she received her DSc (habilitation) degree in in Medical Biology / Neuropsychopharmacology and became an associate professor at Institute of Pharmacology PAS, then in 2004 becoming nominated a professor of medical sciences by the President of the Republic of Poland. She has published over 110 peer-reviewed manuscripts and several book chapters. She has supervised 7 PhD students. The preclinical research conducted in Prof. Nalepa’s lab concerns depression and mechanisms of action of antidepressant drugs, drug dependence, autoimmune diseases, and recently neurodegeneration and a putative role of noradrenergic transmission in neuroprotection against Parkinson’s disease. The lab utilizes an integrated approach to study these issues – spanning from molecular biology, biochemistry, models of genetically modified animals and cells to behavioral analyses.

 

Research interests:

Stress-related disorders; neuroplasticity; depression; antidepressant drugs; neuroscience.

 

Major publications:

Zelek-Molik A., Costanzi M., Rafa-Zabłocka K., Kreiner G., Roman A., Vetulani J., Rossi-Arnaud C., Cestari V., Nalepa I. (2019). “Fear memory-induced alterations in the mRNA expression of G proteins in the mouse brain and the impact of immediate posttraining treatment with morphine”, Prog Neuropsychopharmacol Biol Psychiatry. 93:221-231. doi: 10.1016/j.pnpbp.2019.04.001.

Kreiner G., Rafa-Zabłocka K., Barut J., Chmielarz P., Kot M., Bagińska M., Parlato R., Daniel W.A., Nalepa I. (2019). “Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism”, Sci Rep. 9(1):5262. doi: 10.1038/s41598019-41756-3.

Rafa-Zabłocka K., Kreiner G., Bagińska M., Kuśmierczyk J., Parlato R., Nalepa I. (2017). “Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test”, Sci Rep. 7(1):13515. doi: 10.1038/s41598-017-14069-6.

Chmielarz P., Kreiner G., Kot M., Zelek-Molik A., Kowalska M., Bagińska M., Daniel W.A., Nalepa I. (2015). “Disruption of glucocorticoid receptors in the noradrenergic system leads to BDNF up-regulation and altered serotonergic transmission associated with a depressivelike phenotype in female GR(DBHCre) mice”, Pharmacol Biochem Behav. 137:69-77. doi: 10.1016/j.pbb.2015.08.001.

Coccurello R., Bielawski A., Zelek-Molik A., Vetulani J., Kowalska M., D'Amato F.R., Nalepa I. (2014). “Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice”, Prog Neuropsychopharmacol Biol Psychiatry. 48:161-9. doi: 10.1016/j.pnpbp.2013.10.004.

 mal.fil@if-pan.krakow.pl

@ www.if-pan.krakow.pl

Małgorzata Filip is currently the Head of the Department of Drug Addiction Pharmacology and the Director of Maj Institute of Pharmacology PAS. She received a PhD from the Institute of Pharmacology PAS in Krakow, D. Sci. from the Jagiellonian University Medical College. The President of the Republic of Poland conferred her the title of professor. She completed postdoctoral fellowship or visitor scientist training at the University of Texas Medical Branch in Galveston and at the Medical University of South Carolina in Charleston (USA). Between 2009-2015 she served as the Head of the Department of Toxicology Faculty of Pharmacy Jagiellonian University Medical College. She is a corresponding member of the Polish Academy of Sciences and Polish Academy of Art and Sciences as well as an expert for European Research Council and National Science Centre in Poland.

Research interests:

Neuropharmacology, substance use disorder, mood disorders.

Major publications:

Niedzielska E, Smaga I, Gawlik M, Moniczewski A, Stankowicz P, Pera J, Filip M. (2016) Oxidative Stress in Neurodegenerative Diseases. Mol Neurobiol.

Borroto-Escuela DO, Wydra K, Filip M, Fuxe K. (2018) A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction. Trends Pharmacol Sci.

Smaga I, Fierro D, Mesa J, Filip M, Knackstedt LA. (2020) Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease.  Neurosci Biobehav Rev.

Gawliński D, Gawlińska K, Frankowska M, Filip M. (2020) Maternal high-sugar diet changes offspring vulnerability to reinstatement of cocaine-seeking behavior: Role of melanocortin-4 receptors. FASEB J.

Niedzielska-Andres E, Pomierny-Chamioło L, Andres M, Walczak M, Knackstedt LA, Filip M, Przegaliński E. (2021) Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters.  Pharmacol Ther.

 janrod@if-pan.krakow.pl  

@ http://if-pan.krakow.pl/en/departments/department-of-molecular-neuropharmacology/ 

Our research focuses on two areas: the reward system of the brain and the molecular mechanisms of drug action. 

The reward system of the brain encompasses all brain areas involved in reward-driven behaviors, with the mesolimbic dopamine system at the core. We have been studying the mechanisms involved in the plasticity of dopaminergic and dopaminoceptive neurons, and also the role of endogenous opioids in signaling rewards. 

As the name of the Department implies a large part of our research focuses on the cellular and the molecular mechanisms of actions of psychotropic drugs, also with an emphasis on opioids. We hope that elucidating molecular signatures of drug action will lead to the identification of mechanisms essential for their therapeutic effects. 

 

Research interests:  

molecular neurobiology, reward system, endogenous opioid system 

 

Recent publications:  

Radlicka A, Kamińska K, Borczyk M, Piechota M, Korostyński M, Pera J, Lorenc-Koci E, Rodriguez Parkitna J. (2021) Effects of L-DOPA on Gene Expression in the Frontal Cortex of Rats with Unilateral Lesions of Midbrain Dopaminergic Neurons. eNeuro. 2021 Jan 21;8(1):ENEURO.0234-20.2020. 

Jabłońska J, Szumiec Ł, Zieliński P, Rodriguez Parkitna J. Time elapsed between choices in a probabilistic task correlates with repeating the same decision. Eur J Neurosci. 2021 Feb 8.  

Harda Z, Spyrka J, Jastrzębska K, Szumiec Ł, Bryksa A, Klimczak M, Polaszek M, Gołda S, Zajdel J, Misiołek K, Błasiak A, Rodriguez Parkitna J. (2020) Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity. Neuropharmacology. 2020 Dec 1;180:108307.  

Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC. (2019) The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Cell Rep. 2019 Jun 11;27(11):3182-3198.e9. 

 michkor@if-pan.krakow.pl 

I received a Ph.D. in medical sciences (biomedicine) at the Maj Institute of Pharmacology in Krakow in 2008, and worked there as an associate professor. My research interests include molecular determinants of complex neurological disorders and drug-induced regulation of gene expression. Recently, I focus on highly variable regions of the human genome associated with drug safety and efficacy.  


Research interests: 
 

Pharmacogenomics, Gene regulation, Molecular neuropharmacology. 


Major publications: 
 

Borczyk MPiechota M, Rodriguez Parkitna JKorostynski M. Prospects for personalization of depression treatment with genome sequencing. British Journal of Pharmacology. 2021. In press 

Korostynski M, Morga R, Piechota M, Hoinkis D, Golda S, Dziedzic T, Slowik A, Moskala M, Pera J. Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAs. Mol Neurobiol. 2020 Feb;57(2):988-996.  

Korostynski M, Piechota M, Morga R, Hoinkis D, Golda S, Zygmunt M, Dziedzic T, Moskala M, Slowik A, Pera J. Systemic response to rupture of intracranial aneurysms involves expression of specific gene isoforms. Transl Med. 2019 May 2;17(1):141. 

Zygmunt M, Hoinkis D, Hajto J, Piechota M, Skupień-Rabian B, Jankowska U, Kędracka-Krok S, Rodriguez Parkitna J, Korostynski M. Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs. BMC Neurosci. 2018 Sep 12;19(1):55 

Zygmunt M, Piechota M, Rodriguez Parkitna J, Korostynski M. Decoding the transcriptional programs activated by psychotropic drugs in the brain. Genes Brain Behav. 2018 Aug 7:e12511. 

 szewczyk@if-pan.krakow.pl

Bernadeta Szewczyk is a graduate of the Faculty of Geography and Biology, Pedagogical University of Krakow. After graduation, she joined the Department of Neurobiology at the Institute of Pharmacology, Polish Academy of Sciences, where she still works to date. She defended her doctoral dissertation in 2002 and completed a Postdoctoral Fellowship at the Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi in the United States of America from 2005-2007. Following the completion her fellowship, she resumed work at the Department of Neurobiology IF PAS. In 2017, she received a Postdoctoral Degree in Medical Sciences with specialization in Medical Biology. Currently, she is the head of the Department of Neurobiology.


Research interests: 
 

The role of zinc in the pathophysiology and therapy of depression, with emphasis on the properties of zinc as a modulator of the functions of the glutamatergic and serotonergic systems. 


Major publications: 
 

Rafalo-Ulinska A, Piotrowska J, Kryczyk A, Opoka W, Sowa-Kucma M, Misztak P, Rajkowska G, Stockmeier CA, Datka W, Nowak G, Szewczyk B. Zinc transporters protein level in postmortem brain of depressed subjects and suicide victims. J Psychiatr Res. 2016;83:220-229. 

Szewczyk BPochwat B, Rafało A, Palucha-Poniewiera A, Domin H, Nowak G. Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc. Neuropharmacology. 2015;99:517-2. 

Satała G, Duszyńska B, Stachowicz K, Rafalo A, Pochwat B, Luckhart C, Albert PR, Daigle M, Tanaka KF, Hen R, Lenda T, Nowak G, Bojarski AJ, Szewczyk B. Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies. Mol Neurobiol. 2016;53(10):6869-6881. 

Szewczyk B. Zinc homeostasis and neurodegenerative disorders. Front Aging Neurosci. 2013; 5:33 

 kuter@if-pan.krakow.pl 

@ http://if-pan.krakow.pl/en/departments/employees/90/Katarzyna-Kuter-PhD/  

In 2019 dr Kuter received habilitation and in 2021 became a head of the Department of Neuropsychopharmacology in the Maj Institute of Pharmacology PAS. She received her PhD with honors from the same institute in 2007. She worked abroad during scholarships in Wallenberg Neuroscience Center in Lund, SwedenCharité – Universitätsmedizin in Berlin, Germany and as postdoctoral fellow at the Technische Universität Darmstadt in Darmstadt, Germany 


Research interests: 
 

The main interest of her research is recognition of mechanisms active in the preclinical stages of Parkinson’s Disease. These are bothmechanisms leading to neuronal death as well as those compensating for the deficits in dopaminergic system. Such studies are prerequisite to develop a reliableearly diagnosis and to introduce neuroprotective and disease modifying strategies. The compensatory mechanisms show how big is the endogenous brain plasticity and protective potential as they can mask loss of up to 70% of dopaminergic neurons in the substantia nigra. Dr Kuter studies the role of glial cells and energy metabolism in the possibility to improve functioning of the dopaminergic system. Her group performs studies in animal models focused on several aspects of brain functioning at the level of neural circuits, specific cell types, organelles and particular proteins. The team searches for new biomarkerspharmacological tools and treatments to fight and manage Parkinson’s disease. 

 

Major publications:  

Jurga AM, Paleczna M, Kuter KZ. (2020) Overview of General and Discriminating Markers of Differential Microglia Phenotypes. Front Cell Neurosci. 2020 Aug 6;14:198.  

Kuter KZ, Cenci MA, Carta AR. (2020) The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications. Prog Brain Res. 2020;252:131-168.  

Kuter KZ, Olech Ł, Dencher NA. (2019) Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease. Mitochondrion. 2019 Jul;47:227-237.  

Kuter K, Olech Ł, Głowacka U, Paleczna M. (2019) Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration. Neurochem2019 Jan;148(1):63-79.  

Kuter K, Olech Ł, Głowacka U. (2018)  Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA. Mol Neurobiol2018 Apr;55(4):3049-3066.  

 lason@if-pan.krakow.pl

Władysław Lasoń  got his M.Scat  Faculty of Pharmacy of the Medical Academy in Kraków in 1980 and Ph.D in the Institute of Pharmacology Polish Academy of Sciences, Kraków in 1984. He received post-doctoral training at the Department of Anatomy and Cell Biology, School of Medicine, East Carolina University,  Greenville, NC, USA, and at the Department of Comparative and Physiological Psychology at the Nijmegen University in the Netherlands In the years  1993 - 2020 he has served as Head of the  Department of Experimental Neuroendocrinology, Maj Institute of Pharmacology Polish Academy, and currently he is a Professor in this unit. He has co-authored more than 260 peer-reviewed publications. 

 

Research interests:  

Basic mechanisms of epilepsydepression and neurodegenerative diseases.  

Major publications:  

Jantas D, Chwastek J, Malarz J, Stojakowska A, Lasoń W. (2020) Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell DamageInvolvement of Caspase 3 and Cathepsin D InhibitionBiomolecules. 2020 Nov 9;10(11):1530 

Panek M, Kawalec P, Pilc A, Lasoń W. (2020) Developments in the discovery and design of intranasal antidepressantsExpert Opin Drug Discov. 2020 Oct;15(10):1145-1164 

Jantas D, Chwastek J, Grygier B, Lasoń W. (2020) Neuroprotective Effects of Necrostatin-1 Against Oxidative Stress-Induced Cell Damagean Involvement of Cathepsin D Inhibition. Neurotox Res. 2020 Mar;37(3):525-542 

Kajta M, Rzemieniec J, Wnuk A, Lasoń W.  (2020) Triclocarban impairs autophagy in neuronal cells and disrupts estrogen receptor signaling via hypermethylation of specific genesSci Total Environ. 2020 Jan 20;701:134818 

Basta-Kaim A, Ślusarczyk J, Szczepanowicz K, Warszyński P, Leśkiewicz M, Regulska M, Trojan E, Lasoń W. (2019) Protective effects of polydatin in free and nanocapsulated form on changes caused by lipopolysaccharide in hippocampal organotypic culturesPharmacol Rep. 2019 Aug;71(4):603-613 

 starow@if-pan.krakow.pl

 

She holds M.Sc. degree from Jagiellonian University in Krakow, Poland and Ph.D. degree from Utrecht University, the Netherlands. She received habilitation in 2013 at the Jagiellonian University Medical College and since 2021 holds an academic rank of Professor of Medicine and Health Sciences. She frequently lectures at international meetings, is a member of the British Journal of Pharmacology Editorial Board, she also serves as a reviewer for several scientific journals. Her research interests focus on bridging large gaps in the field of pain neurobiology concerning the pathomechanisms of chronic pain with particular interest in the cannabinoid research.

Dr. Starowicz been involved in studies describing the role of CB1 and TRPV1 receptors’ cross talk in animal models of neuropathic pain. Dr. Starowicz’s research focus is also aimed at the issue of degenerative joint disease, osteoarthritis. Currently, Dr Starowicz’s group is engaged in determining the cannabinoid function in chondrocyte regeneration, in determining the inflammatory component in OA as well as in studying the function of cannabinoid receptor ligands in the regulation of chondrocytes and osteoblast activity.

 

Research interests:

Endocannabinoid system, Pain and inflammation using experimental animal models, chronic pain and reward circuits, Molecular neuropharmacology

 

Major publications:

Mlost J, Kostrzewa M, Borczyk M, Bryk M, Chwastek J, Korostyński M, Starowicz K. (2021) CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development. Biomed Pharmacother. 2021;136:111283.

Mlost J, Wąsik A, Starowicz K. (2019) Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain. Pharmacol Res. 2019;143:40-47.

Malek N, Starowicz K. (2019) Joint problems arising from lack of repair mechanisms: can cannabinoids help? Br J Pharmacol. 2019;176(10):1412-1420.

Korostynski M, Malek N, Piechota M, Starowicz K. (2018) Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model. Funct Integr Genomics. 2018 Jan;18(1):79-87.

Korostyński M, Małek N, Piechota M, Starowicz K. (2017) Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis. Int J Genomics. 2017;2017:1746426

Malek N, Mrugala M, Makuch W, Kolosowska N, Przewlocka B, Binkowski M, Czaja M, Morera E, Di Marzo V, Starowicz K. (2015) A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. Pain. 2015;156(5):890-903.

 gorecka@if-pan.krakow.pl

@ www.if-pan.krakow.pl

@ https://goreckalab.blogspot.com

Within her research interests, in addition to the issue related to the role of neuropeptides in depression and treatment resistant depression (2019 received habilitation for a series of publications on: “The role of neuropeptides, with particular emphasis on prolactin and somatostatin, in the animal model of depression - chronic mild stress (CMS)), an important place of her work is occupied by the issue related to the subject of her PhD thesis defended in 2009: The role of dopamine D1-D2 receptor heterodimerization in the mechanism of action of antipsychotics - in vitro studies. The new possibilities of drug action through GPCR dimers represent an interesting aspect in the design of new, more effective drugs.

Since 2020 she is a head of the Laboratory of Biochemical Pharmacology. Research methods and models used in her group are very advanced, diverse, and constantly developed - from cell cultures to transgenic animals, from radioisotope techniques (saturation and competition analyses, receptor autoradiography) to studies of receptor protein interactions in the brain using the PLA technique, in situ hybridization, RT-PCR and miRNA measurements.


Research interests:

Treatment resistant depression, GPCR dimerization, neuropeptides, schizophrenia, stress


Major publications:

Serum Level of miR-1 and miR-155 as Potential Biomarkers of Stress-Resilience of NET-KO and SWR/J Mice. (2020) Solich J, Kuśmider M, Faron-Górecka A, Pabian P, Kolasa M, Zemła B, Dziedzicka-Wasylewska M. Cells.;9(4):917.

Understanding GPCR dimerization. (2019) Faron-Górecka A, Szlachta M, Kolasa M, Solich J, Górecki A, Kuśmider M, Żurawek D, Dziedzicka-Wasylewska M. Methods Cell Biol.; 149:155-178.

Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex. (2018) Szlachta M, Kuśmider M, Pabian P, Solich J, Kolasa M, Żurawek D, Dziedzicka-Wasylewska M, Faron-Górecka A. Front Mol Neurosci. 2018; 11:40.

Prolactin and its receptors in the chronic mild stress rat model of depression. (2014) Faron-Górecka A, Kuśmider M, Kolasa M, Zurawek D, Gruca P, Papp M, Szafran K, Solich J, Pabian P, Romańska I, Antkiewicz-Michaluk L, Dziedzicka-Wasylewska M. Brain Res.;1555:48-59.

Regulation of somatostatin receptor 2 in the context of antidepressant treatment response in chronic mild stress in rat. (2018) Faron-Górecka A, Kuśmider M, Solich J, Kolasa M, Pabian P, Gruca P, Romańska I, Żurawek D, Szlachta M, Papp M, Antkiewicz-Michaluk L, Dziedzicka-Wasylewska M. Psychopharmacology (Berl). 235(7):2137-2149.

jantas@if-pan.krakow.pl

@ http://if-pan.krakow.pl/en/departments/employees/59/Danuta-Jantas/ 

My research interests are mainly focused on cellular models of neurodegeneration and neuroprotection. In addition to searching for intracellular mechanisms of action of clinically used drugs, I am also interested in investigating new synthetic or natural compounds with neuroprotective or anticancer activities. Recently I am focused on implementation of 3D cellular models and automated image analysis to my research methodology.  


Research interests: 
 

Neurodegeneration, neuroprotection, mechanisms of cell death, metabotropic glutamate receptors, 5-HT7 receptor ligands, nanoparticles for CNS drug delivery, carbon nanomaterials for neuroregeneration, 3D models for neuroprotection/neuroregeneration, biological activities of plant-derived  compounds, neuroblastoma and glioblastoma treatment 


Major publications: 
 

Jantas D, Chwastek J, Malarz J, Stojakowska A, Lasoń W.  (2020) Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition. Biomolecules 2020, 10(11):1530.  

Jantas D, Chwastek J, Grygier B, Lasoń W. (2020) Neuroprotective Effects of Necrostatin-1 Against Oxidative Stress-Induced Cell Damage: an Involvement of Cathepsin D Inhibition. Neurotox Res. 2020, 37(3):525-542.  

Jantas D, Lech T, Gołda S, Pilc A, Lasoń W. (2018) New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Neuropharmacology 2018, 141:223-237. 

Jantas D, Grygier B, Gołda S, Chwastek J, Zatorska J, Tertil (2018) M. An endogenous and ectopic expression of metabotropic glutamate receptor 8 (mGluR8) inhibits proliferation and increases chemosensitivity of human neuroblastoma and glioma cells. Cancer Lett. 2018, 432:1-16. 

Jantas D, Grygier B, Zatorska J, Lasoń W. (2018)  Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State. Basic Clin Pharmacol Toxicol. 2018, 123(4):443-451.  

 stoja@if-pan.krakow.pl

Anna Stojakowska is a senior researcher at the Department of Phytochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences. She graduated, with honours, from the Pharmaceutical Faculty of the Nicolaus Copernicus Medical Academy in Kraków, Poland. As a recipient of scholarschips from the Government of the Kingdom of the Netherlands, she had an occasion to work at the Department of Pharmacognosy of the Leiden University, headed by Professor Robert Verpoorte. She earned her DSc (habilitation) degree in 2008, from the Faculty of Pharmacy of the Jagiellonian University Medical College, and in 2015 she became a head of the Phytochemistry Department in the Institute of Pharmacology PAS. Initially, her research area was plant biotechnology, especially production of secondary metabolites by plant tissue and organ cultures. In recent years, she has been mainly focused on isolation of biologically active metabolites from the chemically less explored taxa of medicinal and food plants.


Research interests
:

Biologically active plant constituents, chemophenetics of the Cichorieae and Inuleae tribes of the Asteraceae (Compositae), functional food, plant tissue culture.


Major publications
:

Kłeczek N., Malarz J., Gierlikowska B., Kiss A.K., Stojakowska A. (2020) Constituents of Xerolekia speciosissima (L.) Anderb. (Inuleae), and Anti-Inflammatory Activity of 7,10-Diisobutyryloxy-8,9-epoxythymyl Isobutyrate. Molecules, 25, 4913.

Malarz J., Michalska K., Stojakowska A. (2021) Stem lettuce and its metabolites: Does the variety make any difference? Foods, 10, 59.

Kłeczek N., Michalak B., Malarz J., Kiss A.K., Stojakowska A. (2019) Carpesium divaricatum Sieb. & Zucc. revisited: Newly identified constituents from aerial parts of the plant and their possible contribution to the biological activity of the plant. Molecules, 24, 1614.

Stojakowska A., Galanty A., Malarz J., Michalik M. (2019) Major terpenoids from Telekia speciosa flowers and their cytotoxic activity in vitro. Nat. Prod. Res., 33, 1804-1808.

Stojakowska A., Michalska K., Kłeczek N., Malarz J., Beharav A. (2018) Phenolics and terpenoids from a wild edible plant Lactuca orientalis (Boiss.) Boiss.: A preliminary study. J. Food Comp. Anal., 69, 20-24


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