Supervisors from Mossakowski Medical Research Institute

apiwkowska@imdik.pan.pl

Agnieszka Piwkowska is a professor in the Mossakowski Medical Research Institute, Polish Academy of Sciences (MMRC PAS) where she has worked for 14 years. Since 2018 she has led the Laboratory of Molecular and Cellular Nephrology in Gdańsk. Piwkowska earned her PhD from the Medical University of Gdańsk and her MSc degree at the Technical University of Gdańsk. Her research interests lie in the area of diabetic nephropathy and insulin signaling pathways.

Research interests:

Diabetic nephropathy, podocyte biology, insulin resistance, filtration barrier permeability, kidney pathology.

Major publications:

Piwkowska  A. et al., (2013). Biochim Biophys Acta.

Piwkowska A. and Cell J. (2017). Physiol.

Rachubik et al., (2018). Cell Physiol Biochem.

Szrejder et al., (2020). Biochim Biophys Acta Mol Basis Dis.

Audzeyenka et al., (2020). Biochim Biophys Acta Mol Cell Res.

 esalinska@imdik.pan.pl

@ http://www.imdik.pan.pl/pl/dzialalnosc-naukowa/zaklady-badawcze/64-zaklad-neurochemii

Prof. Salinska graduated from Warsaw University and started working first at Warsaw Medical Academy and then at MMRC PAS. She received her Ph.D. in this Institute, and afterward, she spent six years at The Open University, Milton Keynes, UK. First, she was at the Royal Society postdoctoral fellowship and Wellcome Trust Research Fellowship, and then she was hired as a research assistant.   Prof. Salinska is connected with the MMRC for more than 20 years. Since 2010, Prof. Salinska is the Head of the Neurochemistry Department in MMRI PAS. The main research interest is related mostly to brain ischemia, neurotoxicity, neurodegenerative diseases, and microRNA. Molecular processes involved in learning and memory formation are also the subject of investigation.

Research interests:

Brain ischemia, neurotoxicity, neurodegenerative diseases, microRNA, molecular processes.

Major publications:

Bratek E, Ziembowicz A, Salinska E. Antioxidants, 2020.

Bronisz A, Salińska E, Chiocca EA, Godlewski J. Cancers, 2020.

Krolik A, Diamandakis D, Zych A, Stafiej A, Salinska E. Neurobiol Learn Mem. 2020.

Godlewski J, Lenart J, Salinska E. Noncoding RNA. 2019; Bratek E, Ziembowicz A, Bronisz A, Salinska E. PLoS One. 2018.

 rfilipkowski@imdik.pan.pl 

Robert Kuba Filipkowski received his PhD at Nencki Institute in Warsaw, spent four years in Cold Spring Harbor Laboratory, NY, and is now a head of the Behavior and Metabolism Research Laboratory at Mossakowski Institute. At the lab, we investigate the ultrasonic vocalizations of mice and rats (relevant publications below). We have designed and developed new behavioral setups based on the playback of recorded vocalizations. It turns out rats emit a lot of vocalizations when presented with pre-recorded calls of other rats (see Olszyński et al. 2020). Particularly, we explore changes in the cardiovascular i.e. heart-rate, and behavioral parameters evoked by the playback during different states of the autonomic nervous system. Also, we describe new types of vocalizations as well as study and analyze exchange of vocalizations between couples and groups of rats as well as mice. Here, we investigate different types of vocalizations in search for their biological meaning and/or patterns of emissions and calls’ exchange. Our new project aims at establishing brain centers responsible for vocal ultrasonic exchange.

Research interests:

Behavior, language, stress, animal communication

Major publications:

Olszyński K.H., Polowy R., Małż M., Boguszewski P.M., Filipkowski R.K. 2020. Playback of alarm and appetitive calls differentially impacts vocal, heart-rate, and motor response in rats. iScience, 23, 101577, 2020.

Cieślik M., Gąssowska-Dobrowolska M., Jęśko H., Czapski G.A., Wilkaniec A., Zawadzka A., Dominiak A., Polowy R., Filipkowski R.K., Boguszewski P.M., Gewartowska M., Frontczak-Baniewicz M., Sun G.Y., Beversdorf D.Q., Adamczyk A. Maternal immune activation induces neuroinflammation and cortical synaptic deficits in the adolescent rat offspring. Int. J. Mol. Sci., 21:4097, 2020.

Gąssowska-Dobrowolska M., Cieślik M., Czapski G.A., Jęśko H., Frontczak-Baniewicz M., Gewartowska M., Dominiak A., Polowy R., Filipkowski R.K., Babiec L., Adamczyk A. Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders. Int. J. Mol. Sci., 21:3576, 2020.

Zieminska E., Toczylowska B., Diamandakis D., Hilgier W., Filipkowski R.K., Polowy R., Orzel J., Gorka M., Lazarewicz J.W. 2018. Glutamate, glutamine and GABA levels in rat brain measured using MRS, HPLC and NMR methods in study of two models of autism. Front. Mol. Neurosci., 2018. DOI: 10.3389/fnmol.2018.00418. eCollection 2018.

Ziemka-Nalecz M., Jaworska J., Sypecka J., Polowy R., Filipkowski R.K., Zalewska T. Sodium butyrate, a histone deacetylase inhibitor, exhibits neuroprotective/neurogenic effects in a rat model of neonatal hypoxia-ischemia. Mol. Neurobiol., 54:5300-18, 2017.

jsypecka@imdik.pan.pl

@ http://www.imdik.pan.pl/en/research-groups/departments/112-neurorepair-department

Joanna Sypecka graduated from Warsaw University (Faculty of Biology) and received her Ph.D. degree in medical science from Mossakowski Medical Research Institute (MMRI).  During the 6-month internship at Lausanne University Hospital (Switzerland) she got particularly interested in searching for effective therapies for neonates who experienced perinatal asphyxia resulting in white matter disorders. Since 2015 she has been the head of Ph. D. studies in MMRI, engaged in organizing didactic activity, and involved in  European projects in human capital. Since 2018 she has been the leader of NeuroRepair DepartmentHer research work is focused on the biology of glial cells, especially investigating the mechanisms of their response to various pathophysiological clues to elaborate and pre-clinical testing potential neuroreparative strategies.    

 

Research interests:  

Biology of glial cells, development of the central nervous system, myelination, white matter disorders, epigenetic regulation of cell commitment and differentiation, neuroreparative strategies  

 

Major publications: 

Janowska J, Gargas J, Ziemka-Nalecz M, Zalewska T, Sypecka J.(2020) Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells. Mol Neurobiol. 2020 Oct;57(10):4250-4268.  

Janowska J, Gargas J, Ziemka-Nalecz M, Zalewska T, Buzanska L, Sypecka J. (2019) Directed glial differentiation and transdifferentiation for neural tissue regeneration. Exp Neurol 319:112813.  

Janowska J, Ziemka-Nalecz M, Sypecka J (2018). The Differentiation of Rat Oligodendroglial Cells Is Highly Influenced by the Oxygen Tension: In Vitro Model Mimicking Physiologically Normoxic Conditions. Int J Mol Sci 24;19(2):331. 

Janowska J, Sypecka J. (2018) Therapeutic Strategies for Leukodystrophic Disorders Resulting from Perinatal Asphyxia: Focus on Myelinating Oligodendrocytes. Mol Neurobiol 55(5):4388-4402  

Ziemka-Nalecz M, Janowska J, Strojek L, Jaworska J, Zalewska T, Frontczak-Baniewicz M, Sypecka J (2018): Impact of neonatal hypoxia ischaemia on oligodendrocyte survival, maturation and myelinating potential. J Cell Mol Med 22(1):207-222  

Sypecka J, Ziemka-Nalecz M, Dragun-Szymczak P, Zalewska T (2017): A simple, xeno-free method for oligodendrocyte generation from human neural stem cells derived from umbilical cord: engagement of gelatinases in cell commitment and differentiation. J Tissue Eng Regen Med 11:1442- 

Jaworska J, Ziemka-Nalecz M, Sypecka JZalewska T, (2017): The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J  neuroinflammation. 14(1):34 IF=5.102; IF5=5.717; Q1 

Ziemka-Nalecz M, Jaworska J, Sypecka JPolowy R, Filipkowski RK, Zalewska T (2017): Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia. Mol Neurobiol. 54(7):5300-5318  

Sypecka JSarnowska A.(2014) The neuroprotective effect exerted by oligodendroglial progenitors on ischemically impaired hippocampal cells. Mol Neurobiol. 49(2):685-701. 

 trygiel@imdik.pan.pl

Tomasz Rygiel graduated as a molecular biologist from the University of Warsaw in 2002. He moved to the Netherlands, where in 2009 he received his Ph.D. from the University of Amsterdam. During his Ph.D. in the Netherlands Cancer Institute, he studied experimental oncology. Subsequently, he performed postdoctoral training in University Medical Center Utrecht, the Netherlands, focusing on immune regulation. In 2012 he started his own research group at the Medical University of Warsaw, where he combines studies of experimental oncology and immune response. In 2015 he co-founded the biotech company Cellis Ltd, which develops new methods of drug delivery to the tumor, using immune cells. From 2021 Tomasz Rygiel pursues immuno-oncology research in Mossakowski Medical Research Centre PAS. Until now, Tomasz Rygiel published thirty scientific publications and several patent applications and was awarded six research grants.

Research interests:

Immune regulation, cancer therapy, myeloid cells, tumor microenvironment

Major publications:

Pilch Z, Tonecka K, Braniewska A, Sas Z, Skorzynski M, Boon L, Golab J, Meyaard L, Rygiel TP. Antitumor Activity of TLR7 Is Potentiated by CD200R Antibody Leading to Changes in the Tumor Microenvironment. Cancer Immunology Research 2018

Tonecka, K; Braniewska, A; Pilch, Z; Sas, Z; Skorzynski, M; Manuali, E; Rygiel, TP. The CD200 Regulates Inflammation in Mice Independently of TNF-α Production. International Journal of Molecular Sciences 2021

Rygiel, TP; Karnam, G; Goverse, G; van der Marel, APJ; Greuter, MJ; van Schaarenburg, RA; Visser, WF; Brenkman, AB; Molenaar, R; Hoek, RM; Mebius, RE; Meyaard, L, CD200-CD200R signaling suppresses anti-tumor responses independently of CD200 expression on the tumor. Oncogene 2012

Karnam, G; Rygiel, TP; Raaben, M; Grinwis, GCM; Coenjaerts, FE; Ressing, ME; Rottier, PJM; de Haan, CAM; Meyaard, L, CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral Infection. PLoS Pathogens 2012

International patent “Cellular targeted pharmaceutically active substance or label delivery system”. WO2017222398A1

X