Centre of Polymer and Carbon Materials, PAS
TJ expertise chemical modifications of Biopolymers. Biopolymer stabilized MNPs. NC hydrogels for biomedical applications.
Fabrication of antibacterial nanocomposite hydrogel patches from biopolymers for wound dressing applications Physical Engineering
phone no. +48 509 908 203
jtippabatini@cmpw-pan.edu.pl
Bacterial infections are the root cause of most chronic wounds. An efficient biocompatible material that mitigates bacterial infection is highly necessitated in the healthcare sector.
The research seeks to investigate the preparation of antibacterial nanocomposite hydrogel patches using the synergistic combination of biopolymers and Biopolymer-capped metal oxide nanoparticles (NPs). Biopolymers are some of the predominant materials used to develop various forms of antibacterial products due to their superior biocompatibility with adaptable cell attachment properties. The main focus of this work is to prepare biopolymer capped metal oxide NPs by a facile hydrothermal method. MNPs will be synthesized from their respective precursors along with biopolymer as a capping agent which avoids the agglomeration of NPs. Thus, it will control the size of the resultant NPs by using sodium hydroxide as a reducing agent. Required particle size ~10 nm of the NPs will be achieved by varying the reaction temperature. The synthesized NPs would be carried out with sophisticated instrumental analysis. The obtained NPs will be combined with biopolymer to prepare ANC hydrogel patches. Antibacterial characteristics of the synthesized NPs and hydrogel patches will be evaluated against Gram-positive and Gram-negative bacteria by the conventional Petri dish method. The study will contribute to the preparation of novel biopolymer-based ANC hydrogel patches with improved antibacterial activity and their potential use in prototype antibacterial wound dressing applications.
Tippabattini Jayaramudu earned his master's and PhD degrees in Polymer Science and Technology from Sri Krishnadevaray University, India, in 2008 and 2014, respectively, and continued his postdoctoral research in several esteemed universities such as Tshwane University of Technology (2014-2015, South Africa), Inha University (2015-2017, South Korea), the University of Talca (2017-2020, Chile), and CIPA (2020-2021, Chile). T. Jayaramudu has about 3 years of the industry experience in India.
Jayaramudu, T., Varaprasad, K., Pyarasani, R. D., Reddy, K. K., Akbari-Fakhrabadi, A., Carrasco-Sánchez, V., & Amalraj, J. (2021). Hydroxypropyl methylcellulose-copper nanoparticle and its nanocomposite hydrogel films for antibacterial application. Carbohydrate Polymers, 254(117302).
Jayaramudu, T., Varaprasad, K., Reddy, K. K., Pyarasani, R. D., Akbari-Fakhrabadi, A., & Amalraj, J. (2020). Chitosan-pluronic based Cu nanocomposite hydrogels for prototype antimicrobial applications. International Journal of Biological Macromolecules, 143, 825–832.
Jayaramudu, T., Varaprasad, K., Sadiku, E. R., & Amalraj, J. (2019). Temperature-sensitive semi-IPN composite hydrogels for antibacterial applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 572, 307–316.
34 M. Curie-Skłodowskiej 41-819 Zabrze, Poland
Supervisor
Prof. Grażyna Adamus
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